利用脂肪参考磁共振成像对散发性包涵体肌炎的肌肉成分进行容积分析:疾病模式、可重复性和自然进展。

IF 2.8 3区 医学 Q2 CLINICAL NEUROLOGY
Muscle & Nerve Pub Date : 2024-12-01 Epub Date: 2024-09-24 DOI:10.1002/mus.28252
John Heerfordt, Markus Karlsson, Midori Kusama, Seiya Ogata, Ryuta Mukasa, Naoki Kiyosawa, Noriko Sato, Per Widholm, Olof Dahlqvist Leinhard, André Ahlgren, Madoka Mori-Yoshimura
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引用次数: 0

摘要

导言/目的:脂肪参照磁共振成像(MRI)已成为测量神经肌肉疾病中肌肉体积和脂肪的一种很有前途的容积测量技术,但在炎症性肌病方面的经验仍然有限。因此,这项研究旨在描述散发性包涵体肌炎(sIBM)在标准化脂肪参考核磁共振成像肌肉体积测量中的表现,包括扫描仪内重复性、自然进展率以及与临床参数的关系:十名肌萎缩性肌病患者在基线(重复测试)和 12 个月后接受了全腿 Dixon MRI 检查。计算了股四头肌、腘绳肌、内收肌、内侧腓肠肌和胫骨前肌的瘦肌肉体积(LMV)、肌肉脂肪率(MFF)和肌肉脂肪浸润(MFI)。此外,还对 IBM 功能评定量表(IBMFRS)和膝关节伸展力量进行了临床评估。基线测试-重测磁共振成像测量结果用于估算受试者内标准偏差(sw)。得出所有参数在 12 个月内的变化情况:所有肌肉的 MRI 测量结果均显示出较高的重复性;LMV 的标准偏差范围为 2.7 至 18.0 mL,MFF 为 0.7-1.3 个百分点 (pp),MFI 为 0.2-0.7 个百分点。在 12 个月内,平均 LMV 下降了 7.4%,而 MFF 和 MFI 分别上升了 3.8 个百分点和 1.8 个百分点。平均 IBMFRS 下降了 2.4,平均膝关节伸展力量下降了 32.8 N:讨论:核磁共振成像测量结果显示,肌肉萎缩和脂肪置换以及肌力和 IBMFRS 下降的重复性很高,12 个月的变化与肌肉萎缩和脂肪置换一致。我们的研究结果表明,脂肪参考核磁共振成像测量适用于评估炎症性肌病的疾病进展和治疗反应。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Volumetric muscle composition analysis in sporadic inclusion body myositis using fat-referenced magnetic resonance imaging: Disease pattern, repeatability, and natural progression.

Introduction/aims: Fat-referenced magnetic resonance imaging (MRI) has emerged as a promising volumetric technique for measuring muscular volume and fat in neuromuscular disorders, but the experience in inflammatory myopathies remains limited. Therefore, this work aimed at describing how sporadic inclusion body myositis (sIBM) manifests on standardized volumetric fat-referenced MRI muscle measurements, including within-scanner repeatability, natural progression rate, and relationship to clinical parameters.

Methods: Ten sIBM patients underwent whole-leg Dixon MRI at baseline (test-retest) and after 12 months. The lean muscle volume (LMV), muscle fat fraction (MFF), and muscle fat infiltration (MFI) of the quadriceps, hamstrings, adductors, medial gastrocnemius, and tibialis anterior were computed. Clinical assessments of IBM Functional Rating Scale (IBMFRS) and knee extension strength were also performed. The baseline test-retest MRI measurements were used to estimate the within-subject standard deviation (sw). 12-month changes were derived for all parameters.

Results: The MRI measurements showed high repeatability in all muscles; sw ranged from 2.7 to 18.0 mL for LMV, 0.7-1.3 percentage points (pp) for MFF, and 0.2-0.7 pp for MFI. Over 12 months, average LMV decreased by 7.4% while MFF and MFI increased by 3.8 pp and 1.8 pp, respectively. Mean IBMFRS decreased by 2.4 and mean knee extension strength decreased by 32.8 N.

Discussion: The MRI measurements showed high repeatability and 12-month changes consistent with muscle atrophy and fat replacement as well as a decrease in both muscle strength and IBMFRS. Our findings suggest that fat-referenced MRI measurements are suitable for assessing disease progression and treatment response in inflammatory myopathies.

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来源期刊
Muscle & Nerve
Muscle & Nerve 医学-临床神经学
CiteScore
6.40
自引率
5.90%
发文量
287
审稿时长
3-6 weeks
期刊介绍: Muscle & Nerve is an international and interdisciplinary publication of original contributions, in both health and disease, concerning studies of the muscle, the neuromuscular junction, the peripheral motor, sensory and autonomic neurons, and the central nervous system where the behavior of the peripheral nervous system is clarified. Appearing monthly, Muscle & Nerve publishes clinical studies and clinically relevant research reports in the fields of anatomy, biochemistry, cell biology, electrophysiology and electrodiagnosis, epidemiology, genetics, immunology, pathology, pharmacology, physiology, toxicology, and virology. The Journal welcomes articles and reports on basic clinical electrophysiology and electrodiagnosis. We expedite some papers dealing with timely topics to keep up with the fast-moving pace of science, based on the referees'' recommendation.
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