评估治疗骨科硬件感染的抗菌疗法持续时间。

IF 3.7 2区生物学 Q2 MICROBIOLOGY

Microbiology spectrum Pub Date : 2024-11-05 Epub Date: 2024-09-30 DOI:10.1128/spectrum.01269-24

Rija Asim, Christian J Fuchs, Nathan A Summers

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引用次数: 0

摘要

骨科硬件感染的最佳抗菌治疗时间尚不明确。我们确定了 216 名骨科硬件感染患者，其中 42 人（19%）后来复发感染。超过 12 周的长期抑制性抗菌治疗与降低复发几率并无明显关联。重要意义对于骨与关节感染的初次治疗后，如果硬件仍在原位，应继续使用抗生素多长时间仍存在争议。这项研究发现，在试图预防复发感染时，持续使用抗生素超过 12 周并无益处。

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Evaluating the duration of antimicrobial therapy for the treatment of orthopedic hardware infections.

The optimal duration of antimicrobial therapy for orthopedic hardware infections is unclear. We identified 216 patients with orthopedic hardware infections, of whom 42 (19%) later had relapsed infection. Chronic suppressive antimicrobial therapy beyond 12 weeks was not significantly associated with lower odds of relapse.IMPORTANCEThere is debate about how long to continue antibiotics after initial treatment of bone and joint infections when hardware remains in place. This study found no benefit from continuing antibiotics longer than 12 weeks when trying to prevent recurrent infection.

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来源期刊

Microbiology spectrum Biochemistry, Genetics and Molecular Biology-Genetics

CiteScore

3.20

自引率

5.40%

发文量

1800

期刊介绍： Microbiology Spectrum publishes commissioned review articles on topics in microbiology representing ten content areas: Archaea; Food Microbiology; Bacterial Genetics, Cell Biology, and Physiology; Clinical Microbiology; Environmental Microbiology and Ecology; Eukaryotic Microbes; Genomics, Computational, and Synthetic Microbiology; Immunology; Pathogenesis; and Virology. Reviews are interrelated, with each review linking to other related content. A large board of Microbiology Spectrum editors aids in the development of topics for potential reviews and in the identification of an editor, or editors, who shepherd each collection.