发育、生理和疾病中的淋巴肌肉细胞概述。

IF 1.9 4区 医学 Q3 HEMATOLOGY
Microcirculation Pub Date : 2024-11-01 Epub Date: 2024-09-27 DOI:10.1111/micc.12887
Guillermo Arroyo-Ataz, Dennis Jones
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引用次数: 0

摘要

淋巴肌细胞(LMC)是淋巴系统正常运作不可或缺的因素,因为它们为淋巴运输提供动力。淋巴肌细胞控制淋巴管的节律性收缩和血管张力--这也是心肌和血管平滑肌的特性。最近的研究加深了我们对调节淋巴肌细胞的分子机制的了解。在这篇综述中,我们讨论了协调 LMC 介导的收缩性的分子途径,并总结了目前有关其发育起源的知识,这些知识可能揭示了 LMC 独特的收缩特性。此外,我们还强调了越来越多的证据表明,LMC 失调与淋巴水肿和其他淋巴管功能障碍相关疾病的发病机制有关。鉴于治疗淋巴水肿的现有疗法在数量和疗效上都很有限,LMCs 为确定旨在改善淋巴管收缩性的新型治疗靶点提供了一个有希望的焦点。在此,我们将讨论健康和疾病中的淋巴管,以及针对淋巴管改善淋巴管功能的治疗策略。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Overview of Lymphatic Muscle Cells in Development, Physiology, and Disease.

Lymphatic muscle cells (LMCs) are indispensable for proper functioning of the lymphatic system, as they provide the driving force for lymph transport. Recent studies have advanced our understanding of the molecular mechanisms that regulate LMCs, which control rhythmic contraction and vessel tone of lymphatic vessels-traits also found in cardiac and vascular smooth muscle. In this review, we discuss the molecular pathways that orchestrate LMC-mediated contractility and summarize current knowledge about their developmental origin, which may shed light on the distinct contractile characteristics of LMCs. Further, we highlight the growing evidence implicating LMC dysregulation in the pathogenesis of lymphedema and other diseases related to lymphatic vessel dysfunction. Given the limited number and efficacy of existing therapies to treat lymphedema, LMCs present a promising focus for identifying novel therapeutic targets aimed at improving lymphatic vessel contractility. Here, we discuss LMCs in health and disease, as well as therapeutic strategies aimed at targeting them to improve lymphatic vessel function.

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来源期刊
Microcirculation
Microcirculation 医学-外周血管病
CiteScore
5.00
自引率
4.20%
发文量
43
审稿时长
6-12 weeks
期刊介绍: The journal features original contributions that are the result of investigations contributing significant new information relating to the vascular and lymphatic microcirculation addressed at the intact animal, organ, cellular, or molecular level. Papers describe applications of the methods of physiology, biophysics, bioengineering, genetics, cell biology, biochemistry, and molecular biology to problems in microcirculation. Microcirculation also publishes state-of-the-art reviews that address frontier areas or new advances in technology in the fields of microcirculatory disease and function. Specific areas of interest include: Angiogenesis, growth and remodeling; Transport and exchange of gasses and solutes; Rheology and biorheology; Endothelial cell biology and metabolism; Interactions between endothelium, smooth muscle, parenchymal cells, leukocytes and platelets; Regulation of vasomotor tone; and Microvascular structures, imaging and morphometry. Papers also describe innovations in experimental techniques and instrumentation for studying all aspects of microcirculatory structure and function.
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