通过新途径调节肠上皮细胞紧密连接屏障

IF 4.5 3区 医学 Q1 GASTROENTEROLOGY & HEPATOLOGY
Priya Arumugam, Kushal Saha, Prashant Nighot
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引用次数: 0

摘要

肠上皮紧密连接(TJ)是一种动态调节的屏障结构,由闭塞蛋白和克劳丁(claudin)家族蛋白组成,通过允许肠腔和浆膜区之间的选择性旁细胞渗透,介导宿主和外部环境之间的相互作用。TJ 是一种高度动态的结构,可在各种外部刺激下不断进行结构重塑。这是由一系列改变 TJ 蛋白表达和定位的细胞内信号通路介导的。TJ 成分的功能失调损害了屏障的平衡,是包括炎症性肠病(IBD)在内的病理情况的一个重要致病因素。以往的研究通过各种体外和体内模型阐明了 TJ 屏障完整性的重要性和关键调控机制。近年来,人们在了解调控 TJ 形成和解体的各种信号通路之间的相互影响方面做出了巨大努力。本综述全面介绍了调节 TJ 屏障和通透性的新机制。我们讨论了离子转运、细胞骨架和细胞外基质蛋白、信号通路以及自噬的细胞存活机制如何调控肠道 TJ 屏障功能的最新证据。我们还提供了一个视角,探讨了 TJ 屏障调节的具体结果。对多种 TJ 屏障调控机制的了解将有助于进一步了解 TJ 屏障缺陷的相关性以及 IBD 的潜在靶分子/途径。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Intestinal Epithelial Tight Junction Barrier Regulation by Novel Pathways.

Intestinal epithelial tight junctions (TJs), a dynamically regulated barrier structure composed of occludin and claudin family of proteins, mediate the interaction between the host and the external environment by allowing selective paracellular permeability between the luminal and serosal compartments of the intestine. TJs are highly dynamic structures and can undergo constant architectural remodeling in response to various external stimuli. This is mediated by an array of intracellular signaling pathways that alters TJ protein expression and localization. Dysfunctional regulation of TJ components compromising the barrier homeostasis is an important pathogenic factor for pathological conditions including inflammatory bowel disease (IBD). Previous studies have elucidated the significance of TJ barrier integrity and key regulatory mechanisms through various in vitro and in vivo models. In recent years, considerable efforts have been made to understand the crosstalk between various signaling pathways that regulate formation and disassembly of TJs. This review provides a comprehensive view on the novel mechanisms that regulate the TJ barrier and permeability. We discuss the latest evidence on how ion transport, cytoskeleton and extracellular matrix proteins, signaling pathways, and cell survival mechanism of autophagy regulate intestinal TJ barrier function. We also provide a perspective on the context-specific outcomes of the TJ barrier modulation. The knowledge on the diverse TJ barrier regulatory mechanisms will provide further insights on the relevance of the TJ barrier defects and potential target molecules/pathways for IBD.

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来源期刊
Inflammatory Bowel Diseases
Inflammatory Bowel Diseases 医学-胃肠肝病学
CiteScore
9.70
自引率
6.10%
发文量
462
审稿时长
1 months
期刊介绍: Inflammatory Bowel Diseases® supports the mission of the Crohn''s & Colitis Foundation by bringing the most impactful and cutting edge clinical topics and research findings related to inflammatory bowel diseases to clinicians and researchers working in IBD and related fields. The Journal is committed to publishing on innovative topics that influence the future of clinical care, treatment, and research.
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