中重度特应性皮炎患者的先进系统治疗:九个亚洲国家和地区执业医师的主要经验。

IF 3.5 3区 医学 Q1 DERMATOLOGY
Dermatology and Therapy Pub Date : 2024-10-01 Epub Date: 2024-09-28 DOI:10.1007/s13555-024-01278-x
Chia-Yu Chu, Ramesh Bhat Marne, Christina Man-Tung Cheung, Le Ngoc Diep, Nopadon Noppakun, Endi Novianto, Maria Lourdes H Palmero, Yong-Kwang Tay, Azizan Noor Zalmy
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引用次数: 0

摘要

简介:近年来,特应性皮炎(AD)的治疗取得了突飞猛进的进展,而亚洲与非亚洲人群在患者治疗过程中存在差异,因此有必要对亚洲特应性皮炎的现状进行回顾:方法:2023年6月,九位地区皮肤科专家召开了一次圆桌会议,讨论中重度特应性皮炎的最佳治疗方法,重点是先进疗法的使用:结果:在亚洲部分地区,疾病对患者生活质量造成的负担、治疗依从性和经济限制被认为是管理中重度 AD 患者的主要问题。与会者一致认为,哈尼芬和拉杰卡的标准或英国特应性皮炎工作组的诊断标准可用于指导 AD 的临床诊断。同时,包括皮肤科生活质量指数和特应性皮炎控制工具在内的患者报告结果量表可与抑郁监测量表一起用于监测AD患者的治疗结果,以便更好地了解个体化治疗。在治疗中重度 AD 时,应在局部治疗失败后尝试光疗,然后使用传统的改变病情抗风湿药物,最后使用生物制剂或 Janus 激酶抑制剂。全身性皮质类固醇激素可作为急性发作的短期疗法。虽然这些先进的治疗方法已知有效,但医生在开具处方时必须考虑到安全问题和局限性:AD 的治疗方法在不断发展,各国的治疗方法也不尽相同。亚洲各国面临的独特挑战要求对亚洲的 AD 患者采取不同的管理方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Advanced Systemic Treatments in Patients with Moderate-to-Severe Atopic Dermatitis: Key Learnings from Physicians Practicing in Nine Asian Countries and Territories.

Introduction: Rapid progress made in the management of atopic dermatitis (AD) in recent years and the differences in patient journey between Asian and non-Asian populations call for a review of current atopic dermatitis landscape in Asia.

Methods: A roundtable meeting with nine regional dermatological experts was held in June 2023 to discuss the optimal management approaches for moderate-to-severe AD, focusing on the use of advanced therapies.

Results: Disease burden on patients' quality of life, treatment adherence, and financial constraints were identified as major concerns when managing patients with moderate-to-severe AD in parts of Asia. It was agreed that the Hanifin and Rajka's criteria or the UK Working Party's Diagnostic Criteria for Atopic Dermatitis can be used to guide the clinical diagnosis of AD. Meanwhile, patient-reported outcome scales including the Dermatology Life Quality Index and Atopic Dermatitis Control Tool can be used alongside depression monitoring scales to monitor treatment outcomes in patients with AD, allowing a better understanding for individualized treatment. When managing moderate-to-severe AD, phototherapy should be attempted after failure with topical treatments, followed by conventional disease-modifying antirheumatic drugs and, subsequently, biologics or Janus kinase inhibitors. Systemic corticosteroids can be used as short-term therapy for acute flares. Although these advanced treatments are known to be effective, physicians have to take into consideration safety concerns and limitations when prescribing these treatments.

Conclusions: Treatments in AD have evolved and its management varies country by country. Unique challenges across Asian countries necessitate a different management approach in Asian patients with AD.

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来源期刊
Dermatology and Therapy
Dermatology and Therapy Medicine-Dermatology
CiteScore
6.00
自引率
8.80%
发文量
187
审稿时长
6 weeks
期刊介绍: Dermatology and Therapy is an international, open access, peer-reviewed, rapid publication journal (peer review in 2 weeks, published 3–4 weeks from acceptance). The journal is dedicated to the publication of high-quality clinical (all phases), observational, real-world, and health outcomes research around the discovery, development, and use of dermatological therapies. Studies relating to diagnosis, pharmacoeconomics, public health and epidemiology, quality of life, and patient care, management, and education are also encouraged. Areas of focus include, but are not limited to all clinical aspects of dermatology, such as skin pharmacology; skin development and aging; prevention, diagnosis, and management of skin disorders and melanomas; research into dermal structures and pathology; and all areas of aesthetic dermatology, including skin maintenance, dermatological surgery, and lasers. The journal is of interest to a broad audience of pharmaceutical and healthcare professionals and publishes original research, reviews, case reports/case series, trial protocols, and short communications. Dermatology and Therapy will consider all scientifically sound research be it positive, confirmatory or negative data. Submissions are welcomed whether they relate to an International and/or a country-specific audience, something that is crucially important when researchers are trying to target more specific patient populations. This inclusive approach allows the journal to assist in the dissemination of quality research, which may be considered of insufficient interest by other journals. The journal appeals to a global audience and receives submissions from all over the world.
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