真核生物中 RNA 结构在 3' 端处理过程中的作用。

IF 6.1 2区 生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY
Jin Xu, Susan Duncan, Yiliang Ding
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引用次数: 0

摘要

将前 mRNA 成熟为功能完善的 mRNA 涉及一系列高度协调的步骤,这些步骤对于真核生物基因的表达至关重要。研究发现,RNA 结构在其中许多步骤(包括裂解、多腺苷酸化和终止)中都起着调控作用。结构探测技术的最新进展有助于揭示新生转录本构象如何促进这些动态的共转录过程。在本综述中,我们将举例说明 RNA 结构如何影响关键加工酶的可及性和/或功能,从而影响 3' 端加工机制的效率和精度。我们还讨论了一些新兴技术,这些技术可进一步加深我们对 RNA 结构介导的 3' 端处理调控的理解。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The role of RNA structure in 3’ end processing in eukaryotes
Maturation of pre-mRNA into fully functional mRNA involves a series of highly coordinated steps that are essential for eukaryotic gene expression. RNA structure has been found to play regulatory roles in many of these steps, including cleavage, polyadenylation, and termination. Recent advances in structure probing techniques have been instrumental in revealing how nascent transcript conformation contributes to these dynamic, co-transcriptional processes. In this review, we present examples where RNA structure affects accessibility and/or function of key processing enzymes, thereby influencing the efficiency and precision of 3′ end processing machinery. We also discuss emerging technologies that could further enhance our understanding of RNA structure mediated regulation of 3’ end processing.
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来源期刊
Current opinion in structural biology
Current opinion in structural biology 生物-生化与分子生物学
CiteScore
12.20
自引率
2.90%
发文量
179
审稿时长
6-12 weeks
期刊介绍: Current Opinion in Structural Biology (COSB) aims to stimulate scientifically grounded, interdisciplinary, multi-scale debate and exchange of ideas. It contains polished, concise and timely reviews and opinions, with particular emphasis on those articles published in the past two years. In addition to describing recent trends, the authors are encouraged to give their subjective opinion of the topics discussed. In COSB, we help the reader by providing in a systematic manner: 1. The views of experts on current advances in their field in a clear and readable form. 2. Evaluations of the most interesting papers, annotated by experts, from the great wealth of original publications. [...] The subject of Structural Biology is divided into twelve themed sections, each of which is reviewed once a year. Each issue contains two sections, and the amount of space devoted to each section is related to its importance. -Folding and Binding- Nucleic acids and their protein complexes- Macromolecular Machines- Theory and Simulation- Sequences and Topology- New constructs and expression of proteins- Membranes- Engineering and Design- Carbohydrate-protein interactions and glycosylation- Biophysical and molecular biological methods- Multi-protein assemblies in signalling- Catalysis and Regulation
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