益生菌、益生菌和合成益生菌对超重或肥胖儿童和青少年心脏代谢风险因素的影响:系统综述和贝叶斯网络荟萃分析。

IF 7.3 1区 农林科学 Q1 FOOD SCIENCE & TECHNOLOGY
Liang Zhang, Fang Wang, Rui Wang, Bowen Sun, Peng Ju Liu
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引用次数: 0

摘要

益生菌、益生元或合生元对超重或肥胖儿童和青少年的疗效仍不确定。本系统性综述通过对随机临床试验(RCTs)进行网络荟萃分析,评估其干预效果。截至 2024 年 1 月 7 日,通过对 4 个电子数据库的检索,共检索到 17 篇论文,报告了 15 项随机临床试验,涉及 820 名参与者。多菌株益生菌(MSP)在降低体重指数(平均差值(MD)-2.13 kg/m2,95% 可信区间(CrI)[-2.7, -1.57])、腰围(MD -1.34 cm,95% 可信区间(CrI)[-2.33, -0.35])、总胆固醇(MD -6.55 mg/dL,95% CrI [-10.61, -2.45])、甘油三酯(MD -3.71 mg/dL,95% CrI [-5.76, -1.67] )、瘦素(MD -3.99 ng/mL,95% CrI [-4.68, -3.3])和超敏 C 反应蛋白(Hs-CRP)(MD -1.21 mg/L,95% CrI [-1.45, -0.97])。复合益生菌能有效降低 BMI-z 评分(MD -0.07,95% CrI [-0.10,-0.04])和低密度脂蛋白胆固醇(MD -1.54 mg/dL,95% CrI [-1.98,-1.09]),但会导致空腹血糖轻微升高(MD 1.12 mg/dL,95% CrI [0.75,1.49])。单一成分益生元和单一菌株益生菌也分别对 BMI 和 Hs-CRP 产生了一些有益影响。中度至低度证据表明,MSP 可能是改善 BMI 和降低血脂、瘦素和 Hs-CRP 水平的潜在选择,这意味着 MSP 可通过调节肠道微生物群来帮助控制小儿肥胖和相关代谢问题。虽然合成益生菌对身体指标和血脂控制有良好作用,但其对血糖的潜在影响使其目前无法替代 MSP 治疗小儿肥胖症。要证实这些发现,还需要进一步开展大规模、精心设计的研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Effects of probiotics, prebiotics, and synbiotics on cardiometabolic risk factors in children and adolescents with overweight or obesity: a systematic review and Bayesian network meta-analysis.

The efficacy of probiotics, prebiotics, or synbiotics in children and adolescents with overweight or obesity remains uncertain. This systematic review evaluates their intervention effects through a network meta-analysis of randomized clinical trials (RCTs). Searches of 4 electronic databases until January 7, 2024, yielded 17 papers reporting on 15 RCTs involving 820 participants. Multiple-strain probiotics (MSP) showed significant efficacy in reducing BMI (Mean Difference (MD) -2.13 kg/m2, 95% credible interval (CrI) [-2.7, -1.57]), waist circumference (MD -1.34 cm, 95% CrI [-2.33, -0.35]), total cholesterol (MD -6.55 mg/dL, 95% CrI [-10.61, -2.45]), triglycerides (MD -3.71 mg/dL, 95% CrI [-5.76, -1.67]), leptin (MD -3.99 ng/mL, 95% CrI [-4.68, -3.3]), and hypersensitive C-reactive protein (Hs-CRP) (MD -1.21 mg/L, 95% CrI [-1.45, -0.97]). Synbiotics were effective in reducing BMI-z score (MD -0.07, 95% CrI [-0.10, -0.04]) and LDL-C (MD -1.54 mg/dL, 95% CrI [-1.98, -1.09]) but led to a slight increase in fasting glucose (MD 1.12 mg/dL, 95% CrI [0.75, 1.49]). Single-ingredient prebiotics and single-strain probiotics also had some beneficial effects on BMI and Hs-CRP, respectively. Moderate to low evidence suggests MSP may be a potential choice for improving BMI and reducing lipids, leptin, and Hs-CRP levels, implying that MSP could aid in managing pediatric obesity and related metabolic issues by modulating the gut microbiota. Although synbiotics show their favorable effects on body metrics and lipid control, their potential impact on blood glucose currently prevents them from being an alternative to MSP for treating pediatric obesity. Further large-scale, well-designed studies are needed to confirm these findings.

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来源期刊
CiteScore
22.60
自引率
4.90%
发文量
600
审稿时长
7.5 months
期刊介绍: Critical Reviews in Food Science and Nutrition serves as an authoritative outlet for critical perspectives on contemporary technology, food science, and human nutrition. With a specific focus on issues of national significance, particularly for food scientists, nutritionists, and health professionals, the journal delves into nutrition, functional foods, food safety, and food science and technology. Research areas span diverse topics such as diet and disease, antioxidants, allergenicity, microbiological concerns, flavor chemistry, nutrient roles and bioavailability, pesticides, toxic chemicals and regulation, risk assessment, food safety, and emerging food products, ingredients, and technologies.
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