丹麦 2 型糖尿病战略研究中心 (DD2) 2010 至 2023 年队列和生物库项目--队列概况更新。

IF 3.4 2区 医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH
Clinical Epidemiology Pub Date : 2024-09-25 eCollection Date: 2024-01-01 DOI:10.2147/CLEP.S469958
Frederik P B Kristensen, Sia K Nicolaisen, Jens S Nielsen, Diana H Christensen, Kurt Højlund, Henning Beck-Nielsen, Jørgen Rungby, Søren G Friborg, Ivan Brandslund, Jens S Christiansen, Peter Vestergaard, Niels Jessen, Michael H Olsen, Mette K Andersen, Torben Hansen, Charlotte Brøns, Allan Vaag, Reimar W Thomsen, Henrik T Sørensen
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引用次数: 0

摘要

目的:本文概述了丹麦2型糖尿病战略研究中心(DD2)的队列和生物库,包括截至2023年入组参与者的基线特征以及入组后的心血管疾病预后和死亡率:自2010年以来,DD2项目在丹麦各地招募了最近由全科医生和医院临床医生诊断出的2型糖尿病(T2DM)患者。项目在入组时收集了来自问卷、临床检查和生物样本的数据。其他基线和纵向随访数据通过与健康登记处的链接获取:从 2010 年到 2023 年,DD2 项目共招募了 11,369 名参与者(41.3% 为女性,中位年龄为 61.4 岁)。中位 T2DM 病程为 1.3 年,中位体重指数(BMI)为女性 31.6 kg/m2,男性 30.5 kg/m2。18.3%的人吸烟,5.7%的人每周饮酒超过14/21单位(女性/男性),17.9%的人称闲暇时间缺乏运动。助产士的原始记录可追溯到 80 多年前,其中 20.2% 的队列参与者有出生体重结论:DD2 队列的详细信息和长期随访,可以提高我们对新诊断 T2DM 患者并发症进展和预防的认识。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The Danish Centre for Strategic Research in Type 2 Diabetes (DD2) Project Cohort and Biobank from 2010 Through 2023-A Cohort Profile Update.

Purpose: This paper provides an overview of the Danish Centre for Strategic Research in Type 2 Diabetes (DD2) cohort and biobank, including baseline characteristics of participants enrolled up to 2023, and post-enrollment rates of cardiovascular disease outcomes and mortality.

Methods: Since 2010, the DD2 project has enrolled individuals with type 2 diabetes mellitus (T2DM) recently diagnosed by general practitioners and by hospital-based clinicians across Denmark. Data from questionnaires, clinical examinations, and biological samples are collected at enrollment. Additional baseline and longitudinal follow-up data are accessed via linkage to health registries.

Results: Between 2010 and 2023, the DD2 project enrolled 11,369 participants (41.3% women, median age 61.4 years). Median T2DM duration at enrollment was 1.3 years, and median BMI was 31.6 kg/m2 for women and 30.5 kg/m2 for men. 18.3% were smokers, 5.7% consumed more than 14/21 units of alcohol weekly (women/men), and 17.9% reported leisure-time physical inactivity. Original midwife records dating back >80 years revealed that 20.2% of cohort participants had birth weights <3000 g. Based on complete hospital contact history 10 years before enrollment, 20.7% of cohort participants had macrovascular complications, 17.0% had microvascular complications, and 21.7% had kidney disease based on eGFR or urine albumin-creatinine measurements. At enrollment, statins were used by 68.2%, antihypertensive drugs by 69.9%, and glucose-lowering drugs by 86.5% of individuals. Median HbA1c was 48 mmol/mol and median LDL cholesterol 2.2 mmol/L. Genome-wide genotyping and biomarker data have been analyzed for over 9000 individuals. During the current follow-up time from the enrollment date (median 7.9 years), incident cardiovascular disease rate has been 13.8 per 1000 person-years and the mortality rate has been 17.6 per 1000 person-years.

Conclusion: The DD2 cohort, with its detailed information and long-term follow up, can improve our understanding of the progression and prevention of complications among individuals with newly diagnosed T2DM.

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来源期刊
Clinical Epidemiology
Clinical Epidemiology Medicine-Epidemiology
CiteScore
6.30
自引率
5.10%
发文量
169
审稿时长
16 weeks
期刊介绍: Clinical Epidemiology is an international, peer reviewed, open access journal. Clinical Epidemiology focuses on the application of epidemiological principles and questions relating to patients and clinical care in terms of prevention, diagnosis, prognosis, and treatment. Clinical Epidemiology welcomes papers covering these topics in form of original research and systematic reviews. Clinical Epidemiology has a special interest in international electronic medical patient records and other routine health care data, especially as applied to safety of medical interventions, clinical utility of diagnostic procedures, understanding short- and long-term clinical course of diseases, clinical epidemiological and biostatistical methods, and systematic reviews. When considering submission of a paper utilizing publicly-available data, authors should ensure that such studies add significantly to the body of knowledge and that they use appropriate validated methods for identifying health outcomes. The journal has launched special series describing existing data sources for clinical epidemiology, international health care systems and validation studies of algorithms based on databases and registries.
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