碱基修饰和 DNA 修复蛋白在 onco-miRNA 处理中的新作用：癌症生物学的新见解。

IF 4.8 3区医学 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Cancer gene therapy Pub Date : 2024-09-25 DOI:10.1038/s41417-024-00836-x

Giovanna Mangiapane, Vito Giuseppe D’Agostino, Gianluca Tell

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引用次数: 0

摘要

肿瘤微RNA（onco-miRNA）是转录后基因表达调控的重要角色，在肿瘤发生中发挥着关键作用。关于onco-miRNAs生物发生过程中涉及的表转录组修饰，以及它们与负责其处理和分类的调控因子之间相互作用的调控，新的信息不断涌现。在这篇综述中，我们重点介绍了碱基修饰、序列基序和二级结构对 miRNAs 处理和分选的贡献。我们重点讨论了 RNA 结合蛋白（RBPs）在这些过程中的几种作用模式。此外，我们还描述了新出现的情况，即某些 DNA 修复蛋白在积极参与这些事件中发挥了意想不到的重要作用，突出了 Apurinic/apyrimidinic endodeoxyribonuclease 1（APE1）的非经典功能所代表的原始干预，APE1 是 DNA 病变碱基切除修复（BER）途径的核心参与者。利用这些新知识将有助于探索新的癌症诊断和治疗策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Emerging roles of bases modifications and DNA repair proteins in onco-miRNA processing: novel insights in cancer biology

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Emerging roles of bases modifications and DNA repair proteins in onco-miRNA processing: novel insights in cancer biology

Onco-microRNAs (onco-miRNAs) are essential players in the post-transcriptional regulation of gene expression and exert a crucial role in tumorigenesis. Novel information about the epitranscriptomic modifications, involved in onco-miRNAs biogenesis, and in the modulation of their interplay with regulatory factors responsible for their processing and sorting are emerging. In this review, we highlight the contribution of bases modifications, sequence motifs, and secondary structures on miRNAs processing and sorting. We focus on several modes of action of RNA binding proteins (RBPs) on these processes. Moreover, we describe the new emerging scenario that shows an unexpected though essential role of selected DNA repair proteins in actively participating in these events, highlighting the original intervention represented by the non-canonical functions of Apurinic/apyrimidinic endodeoxyribonuclease 1 (APE1), a central player in Base Excision Repair (BER) pathway of DNA lesions. Taking advantage of this new knowledge will help in prospecting new cancer diagnostic and therapeutic strategies.

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来源期刊

Cancer gene therapy 医学-生物工程与应用微生物

CiteScore

10.20

自引率

0.00%

发文量

150

审稿时长

4-8 weeks

期刊介绍： Cancer Gene Therapy is the essential gene and cellular therapy resource for cancer researchers and clinicians, keeping readers up to date with the latest developments in gene and cellular therapies for cancer. The journal publishes original laboratory and clinical research papers, case reports and review articles. Publication topics include RNAi approaches, drug resistance, hematopoietic progenitor cell gene transfer, cancer stem cells, cellular therapies, homologous recombination, ribozyme technology, antisense technology, tumor immunotherapy and tumor suppressors, translational research, cancer therapy, gene delivery systems (viral and non-viral), anti-gene therapy (antisense, siRNA & ribozymes), apoptosis; mechanisms and therapies, vaccine development, immunology and immunotherapy, DNA synthesis and repair. Cancer Gene Therapy publishes the results of laboratory investigations, preclinical studies, and clinical trials in the field of gene transfer/gene therapy and cellular therapies as applied to cancer research. Types of articles published include original research articles; case reports; brief communications; review articles in the main fields of drug resistance/sensitivity, gene therapy, cellular therapy, tumor suppressor and anti-oncogene therapy, cytokine/tumor immunotherapy, etc.; industry perspectives; and letters to the editor.