血清orthmin-1是代谢综合征和2型糖尿病患者与脂肪肝相关的代谢功能障碍的潜在生物标志物。

IF 3.7 2区 医学 Q2 ENDOCRINOLOGY & METABOLISM
Xiaohui Lei, HaiYan Chen, YuXin Xu, Zhuoran Yang, Lili Zhang, Cong Wang, Hu Du
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引用次数: 0

摘要

简介代谢功能障碍相关性脂肪肝(MAFLD)是 2 型糖尿病(T2DM)患者的一种常见病。Isthmin-1(ISM1)是一种脂肪因子,能促进葡萄糖摄取,改善葡萄糖耐量和肝脏脂肪变性。尽管 ISM1 已被证明与 T2DM 有关,但其在 MAFLD 和代谢综合征(MetS)患者中的作用仍未得到充分研究。本研究旨在探讨 T2DM 患者血清 ISM1 与 MAFLD 之间的关系,以及 MetS 在这种关联中的潜在参与:共 250 名参与者分为四组:60 名 T2DM 和 MAFLD 患者、60 名新诊断的 T2DM 患者、60 名 MAFLD 患者和 70 名健康对照组。采用酶联免疫吸附法测定血清中的 ISM1 水平。将合并数据中的 ISM1 浓度分布分为四分位,并进行 Cochran-Armitage 趋势检验,以估计四分位数增加的显著趋势:与对照组相比,并存 MAFLD、MetS 和 T2DM 的患者血清中 ISM1 浓度明显升高。超重/肥胖组的血清 ISM1 水平也高于瘦人组。血清 ISM1 水平与体重指数 (BMI)、尿酸、丙氨酸氨基转移酶、天冬氨酸氨基转移酶、总胆固醇 (TC)、低密度脂蛋白胆固醇、空腹胰岛素和胰岛素抵抗稳态模型评估呈正相关,与年龄和高密度脂蛋白胆固醇 (HDL-C) 呈负相关。体重指数(BMI)、总胆固醇(TC)和高密度脂蛋白胆固醇(HDL-C)与血清中的 ISM1 浓度独立相关。MAFLD、T2DM和T2DM伴MAFLD的相对风险随着ISM1四分位数的升高而显著增加。此外,还观察到血清ISM1水平与MetS成分的数量呈正相关,血浆中ISM1水平的升高在一定程度上增加了患MetS的风险:结论:ISM1 与 TG 和 UA 的组合被认为是诊断 MAFLD 和 MetS 的最佳预测因素,这可能是由于它们会加剧代谢状态。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Serum isthmin-1 is a potential biomarker for metabolic dysfunction associated fatty liver disease in patients with metabolic syndrome and type 2 diabetes mellitus.

Introduction: Metabolic dysfunction associated fatty liver disease (MAFLD) is a prevalent condition in patients with type 2 diabetes mellitus (T2DM). Isthmin-1 (ISM1) is an adipokine that promotes glucose uptake and improves glucose tolerance and hepatic steatosis. Although ISM1 has been shown to be associated with T2DM, its role in patients with MAFLD and metabolic syndrome (MetS) remains insufficiently examined. This study aimed to investigate the relationship between serum ISM1 and MAFLD in patients with T2DM and the potential involvement of MetS in this association.

Research design and methods: A total of 250 participants were divided into four groups: 60 patients with T2DM and MAFLD, 60 with newly diagnosed T2DM, 60 with MAFLD, and 70 healthy controls. Serum ISM1 levels were measured using ELISA. The distribution of ISM1 concentration in the combined data was divided into quartiles, and the Cochran-Armitage trend test was performed to estimate the significant trends across increasing quartiles.

Results: Compared with the controls, patients with coexisting MAFLD, MetS, and T2DM exhibited significantly elevated serum ISM1 concentrations. Serum ISM1 levels in the overweight/obese group were also higher than those in the lean group. Serum ISM1 levels were positively correlated with body mass index (BMI), uric acid, alanine aminotransferase, aspartate aminotransferase, total cholesterol (TC), low-density lipoprotein cholesterol, fasting insulin, and homeostasis model assessment of insulin resistance and negatively associated with age and high-density lipoprotein cholesterol (HDL-C). BMI, TC, and HDL-C were independently associated with serum ISM1 concentration. The relative risks for MAFLD, T2DM, and T2DM with MAFLD increased significantly with higher ISM1 quartiles. Furthermore, a positive correlation was observed between serum ISM1 levels and the number of MetS components, with the elevated plasma levels of ISM1 escalating the risk of developing MetS to some extent.

Conclusions: The combination of ISM1 with TG and UA was identified as the best predictive factor for diagnosing MAFLD and MetS, potentially due to their contribution to aggravating the metabolic state.

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来源期刊
BMJ Open Diabetes Research & Care
BMJ Open Diabetes Research & Care Medicine-Endocrinology, Diabetes and Metabolism
CiteScore
9.30
自引率
2.40%
发文量
123
审稿时长
18 weeks
期刊介绍: BMJ Open Diabetes Research & Care is an open access journal committed to publishing high-quality, basic and clinical research articles regarding type 1 and type 2 diabetes, and associated complications. Only original content will be accepted, and submissions are subject to rigorous peer review to ensure the publication of high-quality — and evidence-based — original research articles.
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