探索色氨酸代谢：从代谢疾病的平衡紊乱到诊断和治疗潜力的转变。

IF 5.3 2区医学 Q1 PHARMACOLOGY & PHARMACY

Biochemical pharmacology Pub Date : 2024-09-25 DOI:10.1016/j.bcp.2024.116554

Zhizhong Luo , Yuqing Liu , Xin Wang , Faxin Fan , Zhenzhen Yang , Duosheng Luo

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引用次数: 0

摘要

代谢性疾病的发病率迅速上升，已成为日益严重的全球健康问题。通过产生或改变代谢产物，肠道微生物群在维持人类健康和影响疾病发展方面发挥着举足轻重的作用。这些代谢产物来自宿主本身或外部环境。在微生物与宿主的相互作用系统中，色氨酸（Trp）在代谢过程中发挥着核心作用。色氨酸是人体内必须从膳食中获取的氨基酸，对各种生理功能至关重要。Trp 可在肠道中代谢为三种主要产物：肠道微生物群调节 5-羟色胺（5-HT，血清素）、犬尿氨酸（Kyn）和各种吲哚衍生物的转化。研究发现，Trp 代谢的改变与代谢性疾病（包括肥胖、糖尿病、非酒精性脂肪肝和动脉粥样硬化）的发生和发展之间存在很大的相关性，但尚未对代谢性疾病中的 Trp 代谢物进行全面研究。因此，本综述总结并分析了最新研究，强调进一步研究肠道微生物群中的 Trp 代谢对了解和治疗代谢性疾病的重要性。这对改善人类健康具有潜在意义，并可能引入新的治疗策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Exploring tryptophan metabolism: The transition from disturbed balance to diagnostic and therapeutic potential in metabolic diseases

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Exploring tryptophan metabolism: The transition from disturbed balance to diagnostic and therapeutic potential in metabolic diseases

The rapidly rising prevalence of metabolic diseases has turned them into an escalating global health concern. By producing or altering metabolic products, the gut microbiota plays a pivotal role in maintaining human health and influencing disease development. These metabolites originate from the host itself or the external environment. In the system of interactions between microbes and the host, tryptophan (Trp) plays a central role in metabolic processes. As the amino acid in the human body that must be obtained through dietary intake, it is crucial for various physiological functions. Trp can be metabolized in the gut into three main products: The gut microbiota regulates the transformation of 5-hydroxytryptamine (5-HT, serotonin), kynurenine (Kyn), and various indole derivatives. It has been revealed that a substantial correlation exists between alterations in Trp metabolism and the initiation and progression of metabolic disorders, including obesity, diabetes, non-alcoholic fatty liver disease, and atherosclerosis, but Trp metabolites have not been comprehensively reviewed in metabolic diseases. As such, this review summarizes and analyzes the latest research, emphasizing the importance of further studying Trp metabolism within the gut microbiota to understand and treat metabolic diseases. This carries potential significance for improving human health and may introduce new therapeutic strategies.

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来源期刊

Biochemical pharmacology 医学-药学

CiteScore

10.30

自引率

1.70%

发文量

420

审稿时长

17 days

期刊介绍： Biochemical Pharmacology publishes original research findings, Commentaries and review articles related to the elucidation of cellular and tissue function(s) at the biochemical and molecular levels, the modification of cellular phenotype(s) by genetic, transcriptional/translational or drug/compound-induced modifications, as well as the pharmacodynamics and pharmacokinetics of xenobiotics and drugs, the latter including both small molecules and biologics. The journal''s target audience includes scientists engaged in the identification and study of the mechanisms of action of xenobiotics, biologics and drugs and in the drug discovery and development process. All areas of cellular biology and cellular, tissue/organ and whole animal pharmacology fall within the scope of the journal. Drug classes covered include anti-infectives, anti-inflammatory agents, chemotherapeutics, cardiovascular, endocrinological, immunological, metabolic, neurological and psychiatric drugs, as well as research on drug metabolism and kinetics. While medicinal chemistry is a topic of complimentary interest, manuscripts in this area must contain sufficient biological data to characterize pharmacologically the compounds reported. Submissions describing work focused predominately on chemical synthesis and molecular modeling will not be considered for review. While particular emphasis is placed on reporting the results of molecular and biochemical studies, research involving the use of tissue and animal models of human pathophysiology and toxicology is of interest to the extent that it helps define drug mechanisms of action, safety and efficacy.