Emily N C Manoogian, Michael J Wilkinson, Monica O'Neal, Kyla Laing, Justina Nguyen, David Van, Ashley Rosander, Aryana Pazargadi, Nikko R Gutierrez, Jason G Fleischer, Shahrokh Golshan, Satchidananda Panda, Pam R Taub
{"title":"成人代谢综合征患者的限时进食：随机对照试验。","authors":"Emily N C Manoogian, Michael J Wilkinson, Monica O'Neal, Kyla Laing, Justina Nguyen, David Van, Ashley Rosander, Aryana Pazargadi, Nikko R Gutierrez, Jason G Fleischer, Shahrokh Golshan, Satchidananda Panda, Pam R Taub","doi":"10.7326/M24-0859","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Time-restricted eating (TRE), limiting daily dietary intake to a consistent 8 to 10 hours without mandating calorie reduction, may provide cardiometabolic benefits.</p><p><strong>Objective: </strong>To determine the effects of TRE as a lifestyle intervention combined with current standard-of-care treatments on cardiometabolic health in adults with metabolic syndrome.</p><p><strong>Design: </strong>Randomized controlled trial. (ClinicalTrials.gov: NCT04057339).</p><p><strong>Setting: </strong>Clinical research institute.</p><p><strong>Participants: </strong>Adults with metabolic syndrome including elevated fasting glucose or hemoglobin A<sub>1c</sub> (HbA<sub>1c</sub>; pharmacotherapy allowed).</p><p><strong>Intervention: </strong>Participants were randomly assigned to standard-of-care (SOC) nutritional counseling alone (SOC group) or combined with a personalized 8- to 10-hour TRE intervention (≥4-hour reduction in eating window) (TRE group) for 3 months. Timing of dietary intake was tracked in real time using the myCircadianClock smartphone application.</p><p><strong>Measurements: </strong>Primary outcomes were HbA<sub>1c</sub>, fasting glucose, fasting insulin, homeostasis model assessment of insulin resistance, and glycemic assessments from continuous glucose monitors.</p><p><strong>Results: </strong>108 participants from the TIMET study completed the intervention (89% of those randomly assigned; 56 women, mean baseline age, 59 years; body mass index of 31.22 kg/m<sup>2</sup>; eating window of 14.19 hours). Compared with SOC, TRE improved HbA<sub>1c</sub> by -0.10% (95% CI, -0.19% to -0.003%). Statistical outcomes were adjusted for age. There were no major adverse events.</p><p><strong>Limitation: </strong>Short duration, self-reported diet, potential for multiple elements affecting outcomes.</p><p><strong>Conclusion: </strong>Personalized 8- to 10-hour TRE is an effective practical lifestyle intervention that modestly improves glycemic regulation and may have broader benefits for cardiometabolic health in adults with metabolic syndrome on top of SOC pharmacotherapy and nutritional counseling.</p><p><strong>Primary funding source: </strong>National Institutes of Health.</p>","PeriodicalId":7932,"journal":{"name":"Annals of Internal Medicine","volume":" ","pages":"1462-1470"},"PeriodicalIF":19.6000,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Time-Restricted Eating in Adults With Metabolic Syndrome : A Randomized Controlled Trial.\",\"authors\":\"Emily N C Manoogian, Michael J Wilkinson, Monica O'Neal, Kyla Laing, Justina Nguyen, David Van, Ashley Rosander, Aryana Pazargadi, Nikko R Gutierrez, Jason G Fleischer, Shahrokh Golshan, Satchidananda Panda, Pam R Taub\",\"doi\":\"10.7326/M24-0859\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Time-restricted eating (TRE), limiting daily dietary intake to a consistent 8 to 10 hours without mandating calorie reduction, may provide cardiometabolic benefits.</p><p><strong>Objective: </strong>To determine the effects of TRE as a lifestyle intervention combined with current standard-of-care treatments on cardiometabolic health in adults with metabolic syndrome.</p><p><strong>Design: </strong>Randomized controlled trial. (ClinicalTrials.gov: NCT04057339).</p><p><strong>Setting: </strong>Clinical research institute.</p><p><strong>Participants: </strong>Adults with metabolic syndrome including elevated fasting glucose or hemoglobin A<sub>1c</sub> (HbA<sub>1c</sub>; pharmacotherapy allowed).</p><p><strong>Intervention: </strong>Participants were randomly assigned to standard-of-care (SOC) nutritional counseling alone (SOC group) or combined with a personalized 8- to 10-hour TRE intervention (≥4-hour reduction in eating window) (TRE group) for 3 months. Timing of dietary intake was tracked in real time using the myCircadianClock smartphone application.</p><p><strong>Measurements: </strong>Primary outcomes were HbA<sub>1c</sub>, fasting glucose, fasting insulin, homeostasis model assessment of insulin resistance, and glycemic assessments from continuous glucose monitors.</p><p><strong>Results: </strong>108 participants from the TIMET study completed the intervention (89% of those randomly assigned; 56 women, mean baseline age, 59 years; body mass index of 31.22 kg/m<sup>2</sup>; eating window of 14.19 hours). Compared with SOC, TRE improved HbA<sub>1c</sub> by -0.10% (95% CI, -0.19% to -0.003%). Statistical outcomes were adjusted for age. There were no major adverse events.</p><p><strong>Limitation: </strong>Short duration, self-reported diet, potential for multiple elements affecting outcomes.</p><p><strong>Conclusion: </strong>Personalized 8- to 10-hour TRE is an effective practical lifestyle intervention that modestly improves glycemic regulation and may have broader benefits for cardiometabolic health in adults with metabolic syndrome on top of SOC pharmacotherapy and nutritional counseling.</p><p><strong>Primary funding source: </strong>National Institutes of Health.</p>\",\"PeriodicalId\":7932,\"journal\":{\"name\":\"Annals of Internal Medicine\",\"volume\":\" \",\"pages\":\"1462-1470\"},\"PeriodicalIF\":19.6000,\"publicationDate\":\"2024-11-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Annals of Internal Medicine\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.7326/M24-0859\",\"RegionNum\":1,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/10/1 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q1\",\"JCRName\":\"MEDICINE, GENERAL & INTERNAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Annals of Internal Medicine","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.7326/M24-0859","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/10/1 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"MEDICINE, GENERAL & INTERNAL","Score":null,"Total":0}
Time-Restricted Eating in Adults With Metabolic Syndrome : A Randomized Controlled Trial.
Background: Time-restricted eating (TRE), limiting daily dietary intake to a consistent 8 to 10 hours without mandating calorie reduction, may provide cardiometabolic benefits.
Objective: To determine the effects of TRE as a lifestyle intervention combined with current standard-of-care treatments on cardiometabolic health in adults with metabolic syndrome.
Participants: Adults with metabolic syndrome including elevated fasting glucose or hemoglobin A1c (HbA1c; pharmacotherapy allowed).
Intervention: Participants were randomly assigned to standard-of-care (SOC) nutritional counseling alone (SOC group) or combined with a personalized 8- to 10-hour TRE intervention (≥4-hour reduction in eating window) (TRE group) for 3 months. Timing of dietary intake was tracked in real time using the myCircadianClock smartphone application.
Measurements: Primary outcomes were HbA1c, fasting glucose, fasting insulin, homeostasis model assessment of insulin resistance, and glycemic assessments from continuous glucose monitors.
Results: 108 participants from the TIMET study completed the intervention (89% of those randomly assigned; 56 women, mean baseline age, 59 years; body mass index of 31.22 kg/m2; eating window of 14.19 hours). Compared with SOC, TRE improved HbA1c by -0.10% (95% CI, -0.19% to -0.003%). Statistical outcomes were adjusted for age. There were no major adverse events.
Limitation: Short duration, self-reported diet, potential for multiple elements affecting outcomes.
Conclusion: Personalized 8- to 10-hour TRE is an effective practical lifestyle intervention that modestly improves glycemic regulation and may have broader benefits for cardiometabolic health in adults with metabolic syndrome on top of SOC pharmacotherapy and nutritional counseling.
Primary funding source: National Institutes of Health.
期刊介绍：
Established in 1927 by the American College of Physicians (ACP), Annals of Internal Medicine is the premier internal medicine journal. Annals of Internal Medicine’s mission is to promote excellence in medicine, enable physicians and other health care professionals to be well informed members of the medical community and society, advance standards in the conduct and reporting of medical research, and contribute to improving the health of people worldwide. To achieve this mission, the journal publishes a wide variety of original research, review articles, practice guidelines, and commentary relevant to clinical practice, health care delivery, public health, health care policy, medical education, ethics, and research methodology. In addition, the journal publishes personal narratives that convey the feeling and the art of medicine.
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