通过能量转移光催化将羧酸转化为磺酰胺生物异养生物。

IF 4.9 1区化学 Q1 CHEMISTRY, ORGANIC

Organic Letters Pub Date : 2024-10-11 Epub Date: 2024-10-01 DOI:10.1021/acs.orglett.4c03325

Zhipeng Zong, Jingjing Yang, Lulu Yuan, Xiaojie Wang, Jian-Qiang Chen, Jie Wu

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引用次数: 0

摘要

全球已有 450 多种含有羧酸官能团的药物上市销售。在此，我们报告了一种将羧酸相互转化为生物异构体的简洁而环保的有机光诱导方案。利用这种策略，包括烷基、（杂）芳基和烯基酸在内的多种底物以及各种生物相关酸都能成功转化为伯氨基磺酸。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Conversion of Carboxylic Acids to Sulfonamide Bioisosteres via Energy Transfer Photocatalysis.

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Conversion of Carboxylic Acids to Sulfonamide Bioisosteres via Energy Transfer Photocatalysis.

More than 450 drugs containing a carboxylic acid functional group have been marketed worldwide. Herein, we report a concise and environmentally friendly organic photoinduced protocol for the interconversion of carboxylic acids into their bioisosteres. With this strategy, a variety of substrates, including alkyl, (hetero)aryl, and alkenyl acids, as well as various biologically relevant acids are successfully converted into primary sulfonamides.

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来源期刊

Organic Letters 化学-有机化学

CiteScore

9.30

自引率

11.50%

发文量

1607

审稿时长

1.5 months

期刊介绍： Organic Letters invites original reports of fundamental research in all branches of the theory and practice of organic, physical organic, organometallic,medicinal, and bioorganic chemistry. Organic Letters provides rapid disclosure of the key elements of significant studies that are of interest to a large portion of the organic community. In selecting manuscripts for publication, the Editors place emphasis on the originality, quality and wide interest of the work. Authors should provide enough background information to place the new disclosure in context and to justify the rapid publication format. Back-to-back Letters will be considered. Full details should be reserved for an Article, which should appear in due course.