加拿大儿童队列研究》(Canadian CHILD Cohort Study)中产前维生素 C 和鱼油补充剂的使用与母乳微生物群组成有关。

IF 2.4 Q3 NUTRITION & DIETETICS
Journal of Nutritional Science Pub Date : 2024-09-26 eCollection Date: 2024-01-01 DOI:10.1017/jns.2024.58
Rana F Chehab, Kelsey Fehr, Shirin Moossavi, Padmaja Subbarao, Theo J Moraes, Piushkumar Mandhane, Russell J de Souza, Stuart E Turvey, Ehsan Khafipour, Meghan B Azad, Michele R Forman
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引用次数: 0

摘要

母体饮食可能会调节母乳微生物群,但营养补充剂的影响尚不清楚。我们研究了产前饮食和补充剂的使用与母乳微生物群组成的关系。母亲们分别使用自填式食物频率问卷和标准化问卷报告产前饮食摄入量和补充剂使用情况。采用 16S rRNA 基因测序法对牛奶微生物群进行了分析。使用 Wilcoxon 符号秩检验和多变量模型检验了产前饮食质量、饮食模式和补充剂使用与牛奶微生物群多样性和分类结构之间的关系,并对相关混杂因素进行了调整。参加CHILD队列研究(原名为加拿大健康婴儿纵向发育研究)的645名母亲提供了产后2至6个月期间的一份牛奶样本,并且每周使用产前多种维生素补充剂≥4次。调整混杂因素后,维生素 C 补充剂的使用与牛奶细菌香农多样性呈正相关(β = 0.18,95% CI = 0.05,0.31),与 Veillonella 和 Granulicatella 相对丰度呈负相关(β = 0.54;95% CI = 0.05,1.03 和 β = 0.44;95% CI = 0.04,0.84),与 Finegoldia 相对丰度呈负相关(β = -0.31;95% CI = -0.63,-0.01)。鱼油补充剂的使用与链球菌相对丰度呈正相关(β = 0.26; 95% CI = 0.03, 0.50)。产前饮食质量和饮食模式与牛奶微生物群组成无关。产前维生素 C 和鱼油补充剂的使用与牛奶微生物群组成的差异有关。未来的研究需要证实我们的发现,并阐明母体补充剂的使用与牛奶微生物群和儿童健康之间的关联机制。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Prenatal vitamin C and fish oil supplement use are associated with human milk microbiota composition in the Canadian CHILD Cohort Study.

Maternal diet may modulate human milk microbiota, but the effects of nutritional supplements are unknown. We examined the associations of prenatal diet and supplement use with milk microbiota composition. Mothers reported prenatal diet intake and supplement use using self-administered food frequency and standardised questionnaires, respectively. The milk microbiota was profiled using 16S rRNA gene sequencing. Associations of prenatal diet quality, dietary patterns, and supplement use with milk microbiota diversity and taxonomic structure were examined using Wilcoxon signed-rank tests and multivariable models adjusting for relevant confounders. A subset of 645 mothers participating in the CHILD Cohort Study (originally known as the Canadian Healthy Infant Longitudinal Development Study) provided one milk sample between 2 and 6 months postpartum and used prenatal multivitamin supplements ≥4 times a week. After adjusting for confounders, vitamin C supplement use was positively associated with milk bacterial Shannon diversity (β = 0.18, 95% CI = 0.05, 0.31) and Veillonella and Granulicatella relative abundance (β = 0.54; 95% CI = 0.05, 1.03 and β = 0.44; 95% CI = 0.04, 0.84, respectively), and negatively associated with Finegoldia relative abundance (β = -0.31; 95% CI = -0.63, -0.01). Fish oil supplement use was positively associated with Streptococcus relative abundance (β = 0.26; 95% CI = 0.03, 0.50). Prenatal diet quality and dietary patterns were not associated with milk microbiota composition. Prenatal vitamin C and fish oil supplement use were associated with differences in the milk microbiota composition. Future studies are needed to confirm our findings and elucidate mechanisms linking maternal supplement use to milk microbiota and child health.

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来源期刊
Journal of Nutritional Science
Journal of Nutritional Science NUTRITION & DIETETICS-
CiteScore
3.00
自引率
0.00%
发文量
91
审稿时长
7 weeks
期刊介绍: Journal of Nutritional Science is an international, peer-reviewed, online only, open access journal that welcomes high-quality research articles in all aspects of nutrition. The underlying aim of all work should be, as far as possible, to develop nutritional concepts. JNS encompasses the full spectrum of nutritional science including public health nutrition, epidemiology, dietary surveys, nutritional requirements, metabolic studies, body composition, energetics, appetite, obesity, ageing, endocrinology, immunology, neuroscience, microbiology, genetics, molecular and cellular biology and nutrigenomics. JNS welcomes Primary Research Papers, Brief Reports, Review Articles, Systematic Reviews, Workshop Reports, Letters to the Editor and Obituaries.
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