先天免疫对危险信号的感知：血红素复合物介导的裂解细胞死亡的新机制

IF 40.8 1区医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Signal Transduction and Targeted Therapy Pub Date : 2024-09-30 DOI:10.1038/s41392-024-01985-z

Chintan Chhatbar, Michael Schulz, Roman Sankowski

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引用次数: 0

摘要

Sundaram 及其同事最近在《细胞》（Cell）杂志上发表文章，确定了 NOD 样受体（NLR）家族含 CARD 结构域 5（NLRC5）在血红素介导的细胞死亡和炎症中的新作用1。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Innate immune sensing of danger signals: novel mechanism of heme complex-mediated lytic cell death

查看原文本刊更多论文

Innate immune sensing of danger signals: novel mechanism of heme complex-mediated lytic cell death

In their recent publication in Cell, Sundaram, and colleagues identified a novel role for NOD-like receptor (NLR) family CARD domain containing 5 (NLRC5) in heme-mediated cell death and inflammation.¹ This process is initiated by Toll-like receptors 2 and 4 on the cell surface, which induces intracellular NAD+ depletion and ROS production.

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来源期刊

Signal Transduction and Targeted Therapy Biochemistry, Genetics and Molecular Biology-Genetics

CiteScore

44.50

自引率

1.50%

发文量

384

审稿时长

5 weeks

期刊介绍： Signal Transduction and Targeted Therapy is an open access journal that focuses on timely publication of cutting-edge discoveries and advancements in basic science and clinical research related to signal transduction and targeted therapy. Scope: The journal covers research on major human diseases, including, but not limited to: Cancer,Cardiovascular diseases,Autoimmune diseases,Nervous system diseases.