放射学孤立综合征中的亚历山大症

IF 2.9 3区医学 Q2 CLINICAL NEUROLOGY

Multiple sclerosis and related disorders Pub Date : 2024-09-23 DOI:10.1016/j.msard.2024.105905

Héloise Joly , Emilie Gerbier , Margaux Zerlini , Roxane Fabre , Cassandre Landes-Château , Lydiane Mondot , Mikael Cohen , Christine Lebrun-Frenay

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引用次数: 0

摘要

背景情感障碍是指难以识别（DIF）和描述（DDF）情感和外向思维（EOT）。方法用多伦多情感淡漠量表（TAS-20）测量了29名RIS患者、年龄和性别匹配的健康对照者以及EDSS为3的复发缓解型（RR）多发性硬化症患者的情感淡漠程度。所有参与者都完成了认知（BCCOG-SEP）、抑郁（Fast-BDI）、疲劳（EMIF）和生活质量（SEP-59）的评估。结果三组患者的自闭症程度有显著差异，RRMS 组（平均分 54.5，SD：12.3）的自闭症程度高于 RIS 组（平均分 47.2，SD：14.8）和健康对照组（平均分 41.9，SD：12.8）。34%的 RIS 参与者表现出病态的情感淡漠。这一比例在健康对照组中为 21.7%，在 RRMS 匹配组中为 51.7%。这一差异主要体现在DIF因子上，p<.001。在亚历山大症和不同的认知测量之间没有观察到明显的相关性。在 RIS 组中，情感失调与抑郁和认知疲劳程度密切相关。此外，失认症还与精神生活质量下降有关。有趣的是，没有发现任何认知指标与无言症的程度相关，这与之前的研究结果一致。情感缺失症，主要是难以识别 RIS 患者的情感，与抑郁症有关，但也与认知疲劳和精神生活质量下降有关。这可能会影响 RIS 受试者的日常互动。

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Alexithymia in radiologically isolated syndrome

Background

Alexithymia refers to difficulty identifying (DIF) and describing (DDF) feelings and externally oriented thinking (EOT). Its prevalence remains unknown in the radiologically isolated syndrome (RIS), the preclinical multiple sclerosis (MS) phase.

Methods

Alexithymia was measured with the Toronto Alexithymia Scale (TAS-20) in 29 RIS and age and gender-matched healthy controls and relapsing-remitting (RR) MS with an EDSS <3. All participants completed evaluations of cognition (BCCOG-SEP), depression (Fast-BDI), fatigue (EMIF), and quality of life (SEP-59).

Results

The level of alexithymia was significantly different between the three groups, with the higher score in the RRMS group (mean score of 54.5, SD: 12,3) compared to RIS (mean score of 47.2, SD: 14.8) and in healthy controls (mean score of 41.9, SD:12.8). 34 % of RIS participants showed a pathological level of alexithymia. The proportions were 21.7 % in the healthy controls and 51.7 % in the RRMS-matched groups. The difference was mainly significant for the DIF factor, p<.001. No significant correlations were observed between alexithymia and the different measures of cognition. In the RIS group, alexithymia was strongly linked to the levels of depression and cognitive fatigue. Furthermore, alexithymia was related to decreased mental quality of life.

Conclusion

The study revealed that one-third of subjects with radiologically isolated syndrome show signs of alexithymia. Interestingly, no cognitive measure was found to be correlated with the level of alexithymia, which is consistent with previous research findings. Alexithymia and mainly difficulty identifying feelings in RIS are associated with depression but also relate to cognitive fatigue and reduced mental quality of life. This could impact the daily interactions of RIS subjects.

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来源期刊

Multiple sclerosis and related disorders CLINICAL NEUROLOGY-

CiteScore

5.80

自引率

20.00%

发文量

814

审稿时长

66 days

期刊介绍： Multiple Sclerosis is an area of ever expanding research and escalating publications. Multiple Sclerosis and Related Disorders is a wide ranging international journal supported by key researchers from all neuroscience domains that focus on MS and associated disease of the central nervous system. The primary aim of this new journal is the rapid publication of high quality original research in the field. Important secondary aims will be timely updates and editorials on important scientific and clinical care advances, controversies in the field, and invited opinion articles from current thought leaders on topical issues. One section of the journal will focus on teaching, written to enhance the practice of community and academic neurologists involved in the care of MS patients. Summaries of key articles written for a lay audience will be provided as an on-line resource. A team of four chief editors is supported by leading section editors who will commission and appraise original and review articles concerning: clinical neurology, neuroimaging, neuropathology, neuroepidemiology, therapeutics, genetics / transcriptomics, experimental models, neuroimmunology, biomarkers, neuropsychology, neurorehabilitation, measurement scales, teaching, neuroethics and lay communication.