作为突尼斯多发性硬化症患者诊断和预测生物标志物的神经丝蛋白轻链

IF 2.9 3区医学 Q2 CLINICAL NEUROLOGY

Multiple sclerosis and related disorders Pub Date : 2024-09-21 DOI:10.1016/j.msard.2024.105901

Saloua Mrabet , Ikram Sghaier , Amira Souissi , Alya Gharbi , Youssef Abida , Imen Kacem , Amina Gargouri-Berrechid , Riadh Gouider

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引用次数: 0

摘要

背景与白种人相比，北非人的多发性硬化症（MS）病程更为严重。我们的目的是调查突尼斯多发性硬化症患者队列中的基线脑脊液（CSF）和血清 NfL（sNFL）水平与疾病活动性和残疾累积之间的关联。方法在 Razi 医院神经内科进行了一项横断面研究，包括确诊为多发性硬化症的患者。患者数据来自当地多发性硬化症数据库。采用酶联免疫吸附试验（ELISA）夹心技术测量 sNFL 的水平。结果共纳入 300 名多发性硬化症患者（性别比= 3.05；多发性硬化症发病平均年龄=28.83 岁+9.55，多发性硬化症病程平均=10.21 年+8.96）。多发性硬化症的表型以复发性为主（73%）。脑脊液中的NfL水平与血清中的NfL水平明显相关。NfL浓度与多发性硬化症的活动性（p = 0.012）、疾病进展（p = 0.001）和较高的多发性硬化症严重程度评分（MSSS）（p = 0.0017，r = 0.28）明显相关。

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Neurofilaments light chains as a diagnostic and predictive biomarker for Tunisian Multiple Sclerosis patients

Background

Multiple Sclerosis (MS) course was shown to be more severe among North Africans compared to Caucasians. Validation of prognostic biomarkers of disease activity and severity is a priority in our practice.

Objective

We aimed to investigate the association between baseline cerebrospinal fluid (CSF) and serum NfL (sNFL) levels and disease activity and disability accrual in a cohort of Tunisian patients with MS.

Methods

A cross-sectional study was conducted, in the department of Neurology of Razi Hospital, including patients diagnosed with MS. Patient's data were retrieved from our local MS database. Blood and CSF sampling were performed at the first visit. sNFL levels were measured using the Enzyme-Linked Immuno-Sorbent Assay (ELISA) sandwich technique.

Results

Three hundred MS patients were enrolled (sex-ratio= 3.05; mean age at MS onset=28.83 years+9.55, mean MS course = 10.21 years+8.96). MS phenotype was predominately relapsing (73%). CSF NfL levels were significantly correlated to the serum ones. NfL concentrations were significantly associated with MS activity (p = 0.012), disease progression (p = 0.001), and higher Multiple Sclerosis Severity Scores (MSSS) (p = 0.0017, r = 0.28).

Conclusions

These results support the value of NfL as a sensitive and clinically meaningful CSF and blood biomarker to evaluate MS activity and outcomes among Tunisian MS patients.

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来源期刊

Multiple sclerosis and related disorders CLINICAL NEUROLOGY-

CiteScore

5.80

自引率

20.00%

发文量

814

审稿时长

66 days

期刊介绍： Multiple Sclerosis is an area of ever expanding research and escalating publications. Multiple Sclerosis and Related Disorders is a wide ranging international journal supported by key researchers from all neuroscience domains that focus on MS and associated disease of the central nervous system. The primary aim of this new journal is the rapid publication of high quality original research in the field. Important secondary aims will be timely updates and editorials on important scientific and clinical care advances, controversies in the field, and invited opinion articles from current thought leaders on topical issues. One section of the journal will focus on teaching, written to enhance the practice of community and academic neurologists involved in the care of MS patients. Summaries of key articles written for a lay audience will be provided as an on-line resource. A team of four chief editors is supported by leading section editors who will commission and appraise original and review articles concerning: clinical neurology, neuroimaging, neuropathology, neuroepidemiology, therapeutics, genetics / transcriptomics, experimental models, neuroimmunology, biomarkers, neuropsychology, neurorehabilitation, measurement scales, teaching, neuroethics and lay communication.