在绿色溶剂介质下使用无毒、经济高效的催化剂快速、高效地微波辅助合成新型双吡唑类似物

IF 2.218 Q2 Chemistry

Chemical Data Collections Pub Date : 2024-09-23 DOI:10.1016/j.cdc.2024.101165

Komati Satish Kumar , Alice Rinky Robert , Adapaka Venkateswara Rao , Santosh Kumar Thainana , Singamsetty Harikrishna , Suresh Maddila

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引用次数: 0

摘要

我们提供了一种简便、有效且对环境无害的双吡唑类似物合成方法。这是一个以碳酸氢钠为催化剂的五组分反应，涉及取代苯甲醛、3-氧代丁酸乙酯和苯肼在微波辐照下的反应。该技术的显著优点包括：产率高（93-96%）、易于处理、操作简单、成本效益高、反应曲线清洁、绿色环保、反应时间短（≤ 20 分钟）以及无需柱层析纯化。

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A rapid, efficient microwave-assisted synthesis of novel bis-pyrazole analogues using non-toxic and cost-effective catalyst under green solvent medium

We provide a facile, effective, and environmentally benign synthesis procedure for bis-pyrazole analogues. This is a five-component reaction with sodium bicarbonate acting as a catalyst that involves the reaction between substituted benzaldehyde, ethyl-3-oxobutanoate, and phenylhydrazine, under microwave irradiation. Significant benefits of this technique include high yields (93–96 %), easy handling, simple workup, cost-effectiveness, clean reaction profile, green conditions, short reaction time (≤ 20 min), and no requirement for column chromatography for purification.

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来源期刊

Chemical Data Collections Chemistry-Chemistry (all)

CiteScore

6.10

自引率

0.00%

发文量

169

审稿时长

24 days

期刊介绍： Chemical Data Collections (CDC) provides a publication outlet for the increasing need to make research material and data easy to share and re-use. Publication of research data with CDC will allow scientists to: -Make their data easy to find and access -Benefit from the fast publication process -Contribute to proper data citation and attribution -Publish their intermediate and null/negative results -Receive recognition for the work that does not fit traditional article format. The research data will be published as ''data articles'' that support fast and easy submission and quick peer-review processes. Data articles introduced by CDC are short self-contained publications about research materials and data. They must provide the scientific context of the described work and contain the following elements: a title, list of authors (plus affiliations), abstract, keywords, graphical abstract, metadata table, main text and at least three references. The journal welcomes submissions focusing on (but not limited to) the following categories of research output: spectral data, syntheses, crystallographic data, computational simulations, molecular dynamics and models, physicochemical data, etc.