Naomi Holman, Arthur C. Yelland, Bob Young, Jonathan Valabhji, William Jeffcoate, Fran Game
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Poisson regression models were created to explore risk factors for mortality.</p><h3 data-test=\"abstract-sub-heading\">Results</h3><p>In 71,000 people registered with a new DFU, mortality rates at 12, 26 and 52 weeks was 4.2%, 8.2% and 14.4%, respectively. At 26 weeks, higher mortality rates was associated with older age (rate ratio 2.15; 95% CI 2.03, 2.28, for age ≥80 years vs age 65–79 years), certain ulcer characteristics (area ≥1 cm<sup>2</sup> [1.50; 95% CI 1.42, 1.59], deep ulcers [1.26; 95% CI 1.18, 1.35] or hindfoot location [1.53; 95% CI 1.44, 1.62]) and recorded evidence of ischaemia in the lower limb (1.78; 95% CI 1.69, 1.88) and various comorbidities (heart failure [2.13; 95% CI 2.00, 2.26], myocardial infarction [1.45; 95% CI 1.29, 1.63], stroke [1.37; 95% CI 1.22, 1.53], renal replacement therapy [2.34; 95% CI 2.09, 2.61] and chronic kidney disease stage 3 or greater [1.20; 95% CI 1.12, 1.29]). The 26-week mortality rate exceeded 25% for 7.3% of all individuals, rising to 11.5% of those aged 65 years and older, and 22.1% of those aged 80 years and over.</p><h3 data-test=\"abstract-sub-heading\">Conclusions/interpretation</h3><p>Short-term mortality rates in people with a DFU is high. Teams managing people with DFUs should consider modifying the burdensome interventions and care required to heal such ulcers so maximising the quality of residual life, rather than focusing exclusively on healing.</p><h3 data-test=\"abstract-sub-heading\">Graphical Abstract</h3>\n","PeriodicalId":11164,"journal":{"name":"Diabetologia","volume":"4 1","pages":""},"PeriodicalIF":8.4000,"publicationDate":"2024-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Mortality rates in people presenting with a new diabetes-related foot ulcer: a cohort study with implications for management\",\"authors\":\"Naomi Holman, Arthur C. Yelland, Bob Young, Jonathan Valabhji, William Jeffcoate, Fran Game\",\"doi\":\"10.1007/s00125-024-06262-w\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<h3 data-test=\\\"abstract-sub-heading\\\">Aims/hypothesis</h3><p>People with diabetes-related foot ulcers (DFUs) have high mortality rates. This analysis assesses the impact of selected risk factors on short-term mortality using a population registered in the National Diabetes Foot Care Audit (NDFA).</p><h3 data-test=\\\"abstract-sub-heading\\\">Methods</h3><p>Mortality rates at 12, 26 and 52 weeks was assessed in people with a new DFU registered by a specialist diabetes footcare service in the NDFA in England and Wales between April 2017 and March 2022. Poisson regression models were created to explore risk factors for mortality.</p><h3 data-test=\\\"abstract-sub-heading\\\">Results</h3><p>In 71,000 people registered with a new DFU, mortality rates at 12, 26 and 52 weeks was 4.2%, 8.2% and 14.4%, respectively. At 26 weeks, higher mortality rates was associated with older age (rate ratio 2.15; 95% CI 2.03, 2.28, for age ≥80 years vs age 65–79 years), certain ulcer characteristics (area ≥1 cm<sup>2</sup> [1.50; 95% CI 1.42, 1.59], deep ulcers [1.26; 95% CI 1.18, 1.35] or hindfoot location [1.53; 95% CI 1.44, 1.62]) and recorded evidence of ischaemia in the lower limb (1.78; 95% CI 1.69, 1.88) and various comorbidities (heart failure [2.13; 95% CI 2.00, 2.26], myocardial infarction [1.45; 95% CI 1.29, 1.63], stroke [1.37; 95% CI 1.22, 1.53], renal replacement therapy [2.34; 95% CI 2.09, 2.61] and chronic kidney disease stage 3 or greater [1.20; 95% CI 1.12, 1.29]). The 26-week mortality rate exceeded 25% for 7.3% of all individuals, rising to 11.5% of those aged 65 years and older, and 22.1% of those aged 80 years and over.</p><h3 data-test=\\\"abstract-sub-heading\\\">Conclusions/interpretation</h3><p>Short-term mortality rates in people with a DFU is high. 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引用次数: 0
摘要
目的/假设糖尿病足溃疡(DFU)患者的死亡率很高。本分析以全国糖尿病足护理审计(NDFA)中登记的人群为对象,评估了选定风险因素对短期死亡率的影响。方法对2017年4月至2022年3月期间英格兰和威尔士NDFA中糖尿病足护理专科服务机构登记的新发DFU患者在12周、26周和52周的死亡率进行评估。结果在7.1万名新登记的DFU患者中,12周、26周和52周的死亡率分别为4.2%、8.2%和14.4%。在 26 周时,死亡率较高与年龄较大(年龄≥80 岁与 65-79 岁的比率比为 2.15;95% CI 为 2.03,2.28)、某些溃疡特征(面积≥1 平方厘米 [1.50;95% CI 为 1.42,1.59],深溃疡 [1.26;95% CI 为 1.18,1.35] 或后足位置 [1.53;95% CI 为 1.44,1.62])和有记录的溃疡证据有关。62])以及下肢缺血的记录证据(1.78;95% CI 1.69,1.88)和各种合并症(心力衰竭[2.13;95% CI 2.00,2.26],心肌梗塞[1.45;95% CI 1.29,1.63]、中风[1.37;95% CI 1.22,1.53]、肾脏替代治疗[2.34;95% CI 2.09,2.61]和慢性肾脏病 3 期或以上[1.20;95% CI 1.12,1.29])。7.3%的患者在26周内的死亡率超过25%,65岁及以上的患者死亡率为11.5%,80岁及以上的患者死亡率为22.1%。管理 DFU 患者的团队应考虑改变治愈此类溃疡所需的繁重干预和护理,从而最大限度地提高残余生命的质量,而不是仅仅关注治愈。
Mortality rates in people presenting with a new diabetes-related foot ulcer: a cohort study with implications for management
Aims/hypothesis
People with diabetes-related foot ulcers (DFUs) have high mortality rates. This analysis assesses the impact of selected risk factors on short-term mortality using a population registered in the National Diabetes Foot Care Audit (NDFA).
Methods
Mortality rates at 12, 26 and 52 weeks was assessed in people with a new DFU registered by a specialist diabetes footcare service in the NDFA in England and Wales between April 2017 and March 2022. Poisson regression models were created to explore risk factors for mortality.
Results
In 71,000 people registered with a new DFU, mortality rates at 12, 26 and 52 weeks was 4.2%, 8.2% and 14.4%, respectively. At 26 weeks, higher mortality rates was associated with older age (rate ratio 2.15; 95% CI 2.03, 2.28, for age ≥80 years vs age 65–79 years), certain ulcer characteristics (area ≥1 cm2 [1.50; 95% CI 1.42, 1.59], deep ulcers [1.26; 95% CI 1.18, 1.35] or hindfoot location [1.53; 95% CI 1.44, 1.62]) and recorded evidence of ischaemia in the lower limb (1.78; 95% CI 1.69, 1.88) and various comorbidities (heart failure [2.13; 95% CI 2.00, 2.26], myocardial infarction [1.45; 95% CI 1.29, 1.63], stroke [1.37; 95% CI 1.22, 1.53], renal replacement therapy [2.34; 95% CI 2.09, 2.61] and chronic kidney disease stage 3 or greater [1.20; 95% CI 1.12, 1.29]). The 26-week mortality rate exceeded 25% for 7.3% of all individuals, rising to 11.5% of those aged 65 years and older, and 22.1% of those aged 80 years and over.
Conclusions/interpretation
Short-term mortality rates in people with a DFU is high. Teams managing people with DFUs should consider modifying the burdensome interventions and care required to heal such ulcers so maximising the quality of residual life, rather than focusing exclusively on healing.
期刊介绍:
Diabetologia, the authoritative journal dedicated to diabetes research, holds high visibility through society membership, libraries, and social media. As the official journal of the European Association for the Study of Diabetes, it is ranked in the top quartile of the 2019 JCR Impact Factors in the Endocrinology & Metabolism category. The journal boasts dedicated and expert editorial teams committed to supporting authors throughout the peer review process.