Lubov Stroh , Dennis Nurjadi , Florian Uhle , Thomas Bruckner , Armin Kalenka , Markus Alexander Weigand , Mascha Onida Fiedler-Kalenka
{"title":"高氧重症监护病房患者的肺部事件:动脉血氧分压与编码疾病有关联吗?回顾性分析","authors":"Lubov Stroh , Dennis Nurjadi , Florian Uhle , Thomas Bruckner , Armin Kalenka , Markus Alexander Weigand , Mascha Onida Fiedler-Kalenka","doi":"10.1016/j.medin.2024.04.002","DOIUrl":null,"url":null,"abstract":"<div><h3>Objective</h3><div>Oxygen has been used liberally in ICUs for a long time to prevent hypoxia in ICU- patients. Current evidence suggests that paO<sub>2</sub> >300 mmHg should be avoided, it remains uncertain whether an “optimal level” exists. We investigated how “mild” hyperoxia influences diseases and in-hospital mortality.</div></div><div><h3>Design</h3><div>This is a retrospective study.</div></div><div><h3>Setting</h3><div>112 mechanically ventilated ICU-patients were enrolled.</div></div><div><h3>Patients or participants</h3><div>112 ventilated patients were included and categorized into two groups based on the median paO<sub>2</sub> values measured in initial 24 h of mechanical ventilation: normoxia group (paO<sub>2</sub> ≤ 100 mmHg, n = 43) and hyperoxia group patients (paO<sub>2</sub> > 100 mmHg, n = 69).</div></div><div><h3>Interventions</h3><div>No interventions were performed.</div></div><div><h3>Main variables of interest</h3><div>The primary outcome was the incidence of pulmonary events, the secondary outcomes included the incidence of other new organ dysfunctions and in-hospital mortality.</div></div><div><h3>Results</h3><div>The baseline characteristics, such as age, body mass index, lactate levels, and severity of disease scores, were similar in both groups. There were no statistically significant differences in the incidence of pulmonary events, infections, and new organ dysfunctions between the groups. 27 out of 69 patients (39.1%) in the “mild” hyperoxia group and 12 out of 43 patients (27.9%) in the normoxia group died during their ICU or hospital stay (p = 0.54). The mean APACHE Score was 29.4 (SD 7.9) in the normoxia group and 30.0 (SD 6.7) in the hyperoxia group (p = 0.62).</div></div><div><h3>Conclusions</h3><div>We found no differences in pulmonary events, other coded diseases, and in-hospital mortality between both groups. It remains still unclear what the \"best oxygen regime\" is for intensive care patients.</div></div>","PeriodicalId":49268,"journal":{"name":"Medicina Intensiva","volume":null,"pages":null},"PeriodicalIF":2.7000,"publicationDate":"2024-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Pulmonary Events in ICU patients with hyperoxia: is it possible to relate arterial partial pressure of oxygen to coded diseases? A retrospective analysis\",\"authors\":\"Lubov Stroh , Dennis Nurjadi , Florian Uhle , Thomas Bruckner , Armin Kalenka , Markus Alexander Weigand , Mascha Onida Fiedler-Kalenka\",\"doi\":\"10.1016/j.medin.2024.04.002\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Objective</h3><div>Oxygen has been used liberally in ICUs for a long time to prevent hypoxia in ICU- patients. Current evidence suggests that paO<sub>2</sub> >300 mmHg should be avoided, it remains uncertain whether an “optimal level” exists. We investigated how “mild” hyperoxia influences diseases and in-hospital mortality.</div></div><div><h3>Design</h3><div>This is a retrospective study.</div></div><div><h3>Setting</h3><div>112 mechanically ventilated ICU-patients were enrolled.</div></div><div><h3>Patients or participants</h3><div>112 ventilated patients were included and categorized into two groups based on the median paO<sub>2</sub> values measured in initial 24 h of mechanical ventilation: normoxia group (paO<sub>2</sub> ≤ 100 mmHg, n = 43) and hyperoxia group patients (paO<sub>2</sub> > 100 mmHg, n = 69).</div></div><div><h3>Interventions</h3><div>No interventions were performed.</div></div><div><h3>Main variables of interest</h3><div>The primary outcome was the incidence of pulmonary events, the secondary outcomes included the incidence of other new organ dysfunctions and in-hospital mortality.</div></div><div><h3>Results</h3><div>The baseline characteristics, such as age, body mass index, lactate levels, and severity of disease scores, were similar in both groups. There were no statistically significant differences in the incidence of pulmonary events, infections, and new organ dysfunctions between the groups. 27 out of 69 patients (39.1%) in the “mild” hyperoxia group and 12 out of 43 patients (27.9%) in the normoxia group died during their ICU or hospital stay (p = 0.54). The mean APACHE Score was 29.4 (SD 7.9) in the normoxia group and 30.0 (SD 6.7) in the hyperoxia group (p = 0.62).</div></div><div><h3>Conclusions</h3><div>We found no differences in pulmonary events, other coded diseases, and in-hospital mortality between both groups. 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Pulmonary Events in ICU patients with hyperoxia: is it possible to relate arterial partial pressure of oxygen to coded diseases? A retrospective analysis
Objective
Oxygen has been used liberally in ICUs for a long time to prevent hypoxia in ICU- patients. Current evidence suggests that paO2 >300 mmHg should be avoided, it remains uncertain whether an “optimal level” exists. We investigated how “mild” hyperoxia influences diseases and in-hospital mortality.
Design
This is a retrospective study.
Setting
112 mechanically ventilated ICU-patients were enrolled.
Patients or participants
112 ventilated patients were included and categorized into two groups based on the median paO2 values measured in initial 24 h of mechanical ventilation: normoxia group (paO2 ≤ 100 mmHg, n = 43) and hyperoxia group patients (paO2 > 100 mmHg, n = 69).
Interventions
No interventions were performed.
Main variables of interest
The primary outcome was the incidence of pulmonary events, the secondary outcomes included the incidence of other new organ dysfunctions and in-hospital mortality.
Results
The baseline characteristics, such as age, body mass index, lactate levels, and severity of disease scores, were similar in both groups. There were no statistically significant differences in the incidence of pulmonary events, infections, and new organ dysfunctions between the groups. 27 out of 69 patients (39.1%) in the “mild” hyperoxia group and 12 out of 43 patients (27.9%) in the normoxia group died during their ICU or hospital stay (p = 0.54). The mean APACHE Score was 29.4 (SD 7.9) in the normoxia group and 30.0 (SD 6.7) in the hyperoxia group (p = 0.62).
Conclusions
We found no differences in pulmonary events, other coded diseases, and in-hospital mortality between both groups. It remains still unclear what the "best oxygen regime" is for intensive care patients.
期刊介绍:
Medicina Intensiva is the journal of the Spanish Society of Intensive Care Medicine and Coronary Units (SEMICYUC) and of Pan American and Iberian Federation of Societies of Intensive and Critical Care Medicine. Medicina Intensiva has become the reference publication in Spanish in its field. The journal mainly publishes Original Articles, Reviews, Clinical Notes, Consensus Documents, Images, and other information relevant to the specialty. All works go through a rigorous selection process. The journal accepts submissions of articles in English and in Spanish languages. The journal follows the publication requirements of the International Committee of Medical Journal Editors (ICMJE) and the Committee on Publication Ethics (COPE).