间充质干细胞对严重社区获得性肺炎宿主反应的影响

IF 9 1区医学 Q1 RESPIRATORY SYSTEM

Thorax Pub Date : 2024-09-25 DOI:10.1136/thorax-2024-222026

Tom D Y Reijnders, Pierre-François Laterre, Bruno François, Miguel Sánchez García, Tjitske S R van Engelen, Daoud Sie, Brendon P Scicluna, Dmitry V Ostanin, Kevin J Galinsky, Joe M Butler, Eleuterio Lombardo, Tom van der Poll

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引用次数: 0

摘要

间充质干细胞（MSC）具有免疫调节特性，可改善败血症的病理生理过程。我们对82名随机接受两次Cx611或安慰剂静脉注射的患者，在6个时间点测量了29个血浆生物标志物和血液转录组，从而确定了异体脂肪来源间充质干细胞（Cx611）对社区获得性细菌性肺炎（CABP）引起的脓毒症期间宿主反应的影响。Cx611治疗增强了几种内皮细胞和促凝血反应血浆生物标志物，并导致与先天免疫、止血和细胞凋亡相关的通路表达增加。在CABP引起的败血症中输注Cx611与广泛的宿主反应改变有关。RNAseq数据可从NCBI序列读取档案（SRA）中获得，生物项目编号为PRJNA1097551。本研究中生成和/或分析的其他数据可在合理要求下提供。

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Effect of mesenchymal stem cells on the host response in severe community-acquired pneumonia

Mesenchymal stem cells (MSC) have immune regulatory properties that may ameliorate pathophysiological processes in sepsis. We determined the effect of allogeneic adipose-derived MSCs (Cx611) on the host response during sepsis due to community-acquired bacterial pneumonia (CABP) by measuring 29 plasma biomarkers and blood transcriptomes at six time points in 82 patients randomised to two intravenous infusions of Cx611 or placebo. Cx611 treatment enhanced several endothelial cell and procoagulant response plasma biomarkers, and led to increased expression of pathways related to innate immunity, haemostasis and apoptosis. Cx611 infusion in sepsis due to CABP is associated with broad host response alterations. RNAseq data are available from the NCBI Sequence Read Archive (SRA) under the BioProject accession PRJNA1097551. Other data generated and/or analysed during the current study are available on reasonable request.

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来源期刊

Thorax 医学-呼吸系统

CiteScore

16.10

自引率

2.00%

发文量

197

审稿时长

1 months

期刊介绍： Thorax stands as one of the premier respiratory medicine journals globally, featuring clinical and experimental research articles spanning respiratory medicine, pediatrics, immunology, pharmacology, pathology, and surgery. The journal's mission is to publish noteworthy advancements in scientific understanding that are poised to influence clinical practice significantly. This encompasses articles delving into basic and translational mechanisms applicable to clinical material, covering areas such as cell and molecular biology, genetics, epidemiology, and immunology.