结构决定道路：乳腺癌亚型以不同方式塑造早期脑转移生态位

IF 48.8 1区医学 Q1 CELL BIOLOGY

Cancer Cell Pub Date : 2024-09-26 DOI:10.1016/j.ccell.2024.08.021

Menno Boon, Leila Akkari

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引用次数: 0

摘要

扩散的癌细胞在脑内定植的能力高度依赖于最初的生存线索，往往会引起早期的微环境适应。在本期《癌细胞》（Cancer Cell）杂志上，Gan等人揭示了早期HER2+乳腺癌和三阴性乳腺癌脑转移瘤中不同的肿瘤结构，这些结构形成了基质相互作用，为亚型依赖性患者分层提供了理论依据。

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Architecture sets the path: Breast cancer subtypes differently shape the early brain metastatic niche

The ability of disseminated cancer cells to colonize the brain is highly dependent on initial survival cues, often evoking early microenvironmental adaptations. In this issue of Cancer Cell, Gan et al. unveil disparate tumor architectures in early stage HER2+ breast cancer and triple-negative breast cancer brain metastases that shape stromal interactions, providing a rationale for subtype-dependent patient stratification.

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来源期刊

Cancer Cell 医学-肿瘤学

CiteScore

55.20

自引率

1.20%

发文量

179

审稿时长

4-8 weeks

期刊介绍： Cancer Cell is a journal that focuses on promoting major advances in cancer research and oncology. The primary criteria for considering manuscripts are as follows: Major advances: Manuscripts should provide significant advancements in answering important questions related to naturally occurring cancers. Translational research: The journal welcomes translational research, which involves the application of basic scientific findings to human health and clinical practice. Clinical investigations: Cancer Cell is interested in publishing clinical investigations that contribute to establishing new paradigms in the treatment, diagnosis, or prevention of cancers. Insights into cancer biology: The journal values clinical investigations that provide important insights into cancer biology beyond what has been revealed by preclinical studies. Mechanism-based proof-of-principle studies: Cancer Cell encourages the publication of mechanism-based proof-of-principle clinical studies, which demonstrate the feasibility of a specific therapeutic approach or diagnostic test.