慢性炎症和癌症中的通用和组织特异性成纤维细胞

IF 48.8 1区医学 Q1 CELL BIOLOGY

Cancer Cell Pub Date : 2024-09-26 DOI:10.1016/j.ccell.2024.08.022

Simon Koplev, Sarah A. Teichmann

引用次数: 0

摘要

在本期《癌细胞》（Cancer Cell）杂志上，Gao 等人绘制了肿瘤和慢性炎症组织中成纤维细胞的多样性图谱。作者发现了普遍的成纤维细胞亚型，如 LRRC15+ 和 MMP1+ 肌成纤维细胞，以及专门的组织特异性亚型。他们揭示了成纤维细胞通过基质壁龛和细胞-细胞相互作用在免疫抑制中的细胞作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Universal and tissue-specific fibroblasts in chronic inflammation and cancer

In this issue of Cancer Cell, Gao et al. map fibroblast diversity across tumors and chronic inflammatory tissues. The authors uncover universal fibroblast subtypes such as LRRC15⁺ and MMP1⁺ myofibroblasts along with specialized tissue-specific subtypes. They reveal cellular roles of fibroblasts in immunosuppression through stromal niches and cell-cell interactions.

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来源期刊

Cancer Cell 医学-肿瘤学

CiteScore

55.20

自引率

1.20%

发文量

179

审稿时长

4-8 weeks

期刊介绍： Cancer Cell is a journal that focuses on promoting major advances in cancer research and oncology. The primary criteria for considering manuscripts are as follows: Major advances: Manuscripts should provide significant advancements in answering important questions related to naturally occurring cancers. Translational research: The journal welcomes translational research, which involves the application of basic scientific findings to human health and clinical practice. Clinical investigations: Cancer Cell is interested in publishing clinical investigations that contribute to establishing new paradigms in the treatment, diagnosis, or prevention of cancers. Insights into cancer biology: The journal values clinical investigations that provide important insights into cancer biology beyond what has been revealed by preclinical studies. Mechanism-based proof-of-principle studies: Cancer Cell encourages the publication of mechanism-based proof-of-principle clinical studies, which demonstrate the feasibility of a specific therapeutic approach or diagnostic test.