印度尼西亚巴布亚地区结核分枝杆菌 1 系的描述

IF 2.8 3区医学 Q3 IMMUNOLOGY

Tuberculosis Pub Date : 2024-09-14 DOI:10.1016/j.tube.2024.102568

Hanif A.K. Djunaedy , Clarissa A. Febinia , Raph L. Hamers , Kevin Baird , Iqbal Elyazar , Nguyen Thuy Thuong Thuong , Hidayat Trimarsanto , Safarina G. Malik , Guy Thwaites , Reinout van Crevel , Bachti Alisjahbana , Lidya Chaidir , Philip M. Ashton

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引用次数: 0

摘要

印度尼西亚的结核病（TB）患者中，感染结核分枝杆菌（MTB）1系（L1）的人数位居第三。这些 MTB L1 病例大多出现在印尼最东部偏远的巴布亚省，该省是印尼最不发达的省份之一，结核病发病率特别高。在这项研究中，我们对 42 个 MTB L1 分离物进行了测序和描述，这些分离物来自一个特征明确的患者群体。我们发现 MTB L1 群体的基因具有多样性，病原体基因相关性与居住地或病原体基因相关性与患者种族之间没有关联，这可能反映了不同地区和种族之间的混合或我们的取样比例较低。只有一小部分出现了与耐药性相关的基因变异（5/42，11.9%），这可能是由于缺乏有效的治疗方案。由于 L1.2.1.2.1 的比例较高（30/42，71.4%），巴布亚分离株与其他东南亚岛国（尤其是东帝汶和菲律宾）有相似之处。这项研究填补了印尼巴布亚地区 MTB L1 研究的空白，应成为该地区进一步研究的基石。

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A description of lineage 1 Mycobacterium tuberculosis from papua, Indonesia

Indonesia has the third highest number of tuberculosis (TB) patients infected with Mycobacterium tuberculosis (MTB) Lineage 1 (L1). Most of these MTB L1 cases can be found in Indonesia's remote easternmost province of Papua, one of Indonesia's most underdeveloped provinces with a particularly high burden for TB. In this study, we sequenced and described 42 MTB L1 isolates from a well-characterized cohort of patients. We found a genetically diverse MTB L1 population with no association between pathogen genetic relatedness and place of residence or pathogen genetic relatedness and patient ethnicity, which could reflect mixing between different locales and ethnicities or our low sampling fraction. Only a small number showed genetic variants associated with drug resistance (5/42, 11.9 %), probably due to a lack of effective treatment programs. The Papuan isolates showed similarities to other Island Southeast Asian Countries due to the high proportion of L1.2.1.2.1 (30/42, 71.4 %), especially East Timor and the Philippines. This study fills a research gap of MTB L1 in Indonesian Papua and should serve as a stepping stone for further research in the region.

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来源期刊

Tuberculosis 医学-呼吸系统

CiteScore

4.60

自引率

3.10%

发文量

审稿时长

49 days

期刊介绍： Tuberculosis is a speciality journal focusing on basic experimental research on tuberculosis, notably on bacteriological, immunological and pathogenesis aspects of the disease. The journal publishes original research and reviews on the host response and immunology of tuberculosis and the molecular biology, genetics and physiology of the organism, however discourages submissions with a meta-analytical focus (for example, articles based on searches of published articles in public electronic databases, especially where there is lack of evidence of the personal involvement of authors in the generation of such material). We do not publish Clinical Case-Studies. Areas on which submissions are welcomed include: -Clinical TrialsDiagnostics- Antimicrobial resistance- Immunology- Leprosy- Microbiology, including microbial physiology- Molecular epidemiology- Non-tuberculous Mycobacteria- Pathogenesis- Pathology- Vaccine development. This Journal does not accept case-reports. The resurgence of interest in tuberculosis has accelerated the pace of relevant research and Tuberculosis has grown with it, as the only journal dedicated to experimental biomedical research in tuberculosis.