氧气填充金属有机框架 (MOFs) 输送系统：可注射氧气的假想设计

IF 2.1 4区医学 Q3 MEDICINE, RESEARCH & EXPERIMENTAL

Medical hypotheses Pub Date : 2024-09-18 DOI:10.1016/j.mehy.2024.111489

Chitrangda Singh , Chandan Bhogendra Jha , Sreedevi Upadhyayula , Rashi Mathur

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引用次数: 0

摘要

氧气输送系统在重症监护医学中至关重要，尤其是在处理急性呼吸窘迫时。本研究提出了一种新方法，探索金属有机框架（MOFs）作为氧气输送系统的潜力。我们强调了它们的独特性能以及在医疗环境中增强氧合的潜力。了解它们的生物相容性、携氧能力和可控释放机制是成功应用于临床实践的关键。MOFs 具有优异的多孔性、结构多样性、较低的晶体密度和可调性，为开发创新型氧气载体提供了全新的视角。我们认为，MOFs 将展现出生物兼容性、稳定性以及在生物体内静脉注射氧气时以可控和持续的方式输送氧气的能力。气体吸附和分子模拟技术将证明氧气在 MOFs 中的可逆结合，并预测受控释放动力学。模拟和实验结果应能表明，利用 MOFs 作为静脉注射氧载体的可行性，其氧释放行为是可控和可逆的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Oxygen Gas-Filled Metal-Organic Frameworks (MOFs) Delivery System: A Hypothetical Design for Injectable Oxygen

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Oxygen Gas-Filled Metal-Organic Frameworks (MOFs) Delivery System: A Hypothetical Design for Injectable Oxygen

Oxygen delivery systems are crucial in critical care medicine, particularly for managing acute respiratory distress. This study presents a novel approach, exploring the potential of Metal-Organic Frameworks (MOFs) as oxygen delivery systems. We highlight their unique properties and potential for enhancing oxygenation in medical settings. Understanding their biocompatibility, oxygen-carrying capacity, and controlled release mechanisms is pivotal for successful implementation in clinical practice. Thanks to their exceptional porosity, structural diversity, lower crystal density, and tunability, MOFs offer a fresh perspective on developing innovative oxygen carriers. We propose that MOFs will demonstrate biocompatibility, stability, and the ability to deliver oxygen in a controlled and sustained manner when administered intravenously in living organisms. Gas adsorption and molecular simulation techniques will demonstrate reversible oxygen binding within MOFs and predict controlled release kinetics. The findings of the simulations and experiments should indicate the feasibility of utilising MOFs as intravenous oxygen carriers with controlled and reversible oxygen release behaviour.

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来源期刊

Medical hypotheses 医学-医学：研究与实验

CiteScore

10.60

自引率

2.10%

发文量

167

审稿时长

60 days

期刊介绍： Medical Hypotheses is a forum for ideas in medicine and related biomedical sciences. It will publish interesting and important theoretical papers that foster the diversity and debate upon which the scientific process thrives. The Aims and Scope of Medical Hypotheses are no different now from what was proposed by the founder of the journal, the late Dr David Horrobin. In his introduction to the first issue of the Journal, he asks ''what sorts of papers will be published in Medical Hypotheses? and goes on to answer ''Medical Hypotheses will publish papers which describe theories, ideas which have a great deal of observational support and some hypotheses where experimental support is yet fragmentary''. (Horrobin DF, 1975 Ideas in Biomedical Science: Reasons for the foundation of Medical Hypotheses. Medical Hypotheses Volume 1, Issue 1, January-February 1975, Pages 1-2.). Medical Hypotheses was therefore launched, and still exists today, to give novel, radical new ideas and speculations in medicine open-minded consideration, opening the field to radical hypotheses which would be rejected by most conventional journals. Papers in Medical Hypotheses take a standard scientific form in terms of style, structure and referencing. The journal therefore constitutes a bridge between cutting-edge theory and the mainstream of medical and scientific communication, which ideas must eventually enter if they are to be critiqued and tested against observations.