使用生物制剂治疗胃癌的靶向和联合免疫疗法:最新进展。

IF 3.6 3区 医学 Q2 BIOTECHNOLOGY & APPLIED MICROBIOLOGY
Expert Opinion on Biological Therapy Pub Date : 2024-10-01 Epub Date: 2024-10-04 DOI:10.1080/14712598.2024.2401622
Jane E Rogers, Qiong Gan, Rebecca E Waters, Ashley A Horak, Jaffer A Ajani
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引用次数: 0

摘要

简介胃腺癌(GAC)仍是一种全球流行的癌症,其发病率在南美洲呈上升趋势。胃腺癌的异质性给治疗带来了挑战:尽管存在挑战,但最新的治疗目标正在使治疗个体化。对于微卫星不稳定性高/错配修复缺陷的定位性疾病,免疫疗法现已被采用。在晚期不可切除的情况下,那些携带人类表皮生长因子受体-2(HER2)表达的患者仍然是一个独立的个体:未来的靶点正在开发中。专家观点:未来的靶点正在开发中,其中包括白蛋白18.2(CLDN18.2)、成纤维细胞生长因子受体2b(FGFR2b)和滋养层细胞表面抗原-2(TROP-2)。唑贝妥昔单抗是一种抗CLDN18.2的单克隆抗体,预计将很快获得美国食品及药物管理局的批准。此外,抗 FGFR2b 单克隆抗体贝马单抗(bemarituzumab)在与化疗联合治疗 HER2 阴性、FGFR2 过度表达的 GAC 患者方面也有改善。目前正在对这一组合进行 3 期试验研究。最后,TROP-2 已成为令人兴奋的实体瘤靶点,预计将在 GAC 中进行研究。所有这三个治疗靶点在近几年都有大量的药物开发,我们预计在未来几年会有更新的靶向药物来推动 GAC 的治疗决策。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Targeted and combination immunotherapies using biologics for gastric cancer: the state-of-the-art.

Introduction: Gastric adenocarcinoma (GAC) remains a prevalent cancer worldwide and its incidence is increasing in South America. The heterogenous nature of GAC makes advances in management challenging.

Areas covered: Despite challenges, recent therapeutic targets are individualizing treatment. For localized disease with microsatellite-instability-high/deficient mismatch repair, immunotherapy is now an adopted practice. In the advanced unresectable setting, those harboring human epidermal growth factor receptor-2 (HER2) expression continue to be a separate entity.

Expert opinion: Future targets are developing. Among these include claudin 18.2 (CLDN18.2), fibroblast growth factor receptor 2b (FGFR2b), and trophoblast cell surface antigen-2 (TROP-2). FDA approval of zolbetuximab's, an anti-CLDN 18.2 monoclonal antibody, is expected soon. Additionally, bemarituzumab, ananti-FGFR2b monoclonal antibody, has shown improvements in combination with chemotherapy in those with HER2 negative GAC with FGFR2 overexpression. This combination is now being investigated in a phase 3 trial. Lastly, TROP-2 has emerged as an exciting solid tumor target and study is expected in GAC. All three of these therapeutic targets have seen an abundance of drug development in recent years, and we anticipate newer targeted agents driving therapeutic decisions in GAC in the coming years.

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来源期刊
Expert Opinion on Biological Therapy
Expert Opinion on Biological Therapy 医学-生物工程与应用微生物
CiteScore
8.60
自引率
0.00%
发文量
96
审稿时长
3-8 weeks
期刊介绍: Expert Opinion on Biological Therapy (1471-2598; 1744-7682) is a MEDLINE-indexed, international journal publishing peer-reviewed research across all aspects of biological therapy. Each article is structured to incorporate the author’s own expert opinion on the impact of the topic on research and clinical practice and the scope for future development. The audience consists of scientists and managers in the healthcare and biopharmaceutical industries and others closely involved in the development and application of biological therapies for the treatment of human disease. The journal welcomes: Reviews covering therapeutic antibodies and vaccines, peptides and proteins, gene therapies and gene transfer technologies, cell-based therapies and regenerative medicine Drug evaluations reviewing the clinical data on a particular biological agent Original research papers reporting the results of clinical investigations on biological agents and biotherapeutic-based studies with a strong link to clinical practice Comprehensive coverage in each review is complemented by the unique Expert Collection format and includes the following sections: Expert Opinion – a personal view of the data presented in the article, a discussion on the developments that are likely to be important in the future, and the avenues of research likely to become exciting as further studies yield more detailed results; Article Highlights – an executive summary of the author’s most critical points.
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