肿瘤与微环境之间的相互影响:空间转录组学的启示。

Advances in cancer research Pub Date : 2024-01-01 Epub Date: 2024-07-15 DOI:10.1016/bs.acr.2024.06.009
Malvika Sudhakar, Harie Vignesh, Kedar Nath Natarajan
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引用次数: 0

摘要

癌症是一种动态疾病,克隆异质性在肿瘤发生、发展和抗药性方面起着根本性的作用。单细胞和空间多模态技术可提供高分辨率的分子图谱,显示涉及肿瘤内部和外部异质性以及与微环境相互作用的潜在基因组、表观基因组和转录组改变。在这篇综述中,我们从一个角度探讨了驱动癌症异质性、肿瘤演化和克隆状态的因素。我们简要介绍了空间转录组技术,并总结了揭示肿瘤状态、细胞间通讯和重塑局部微环境之间动态相互作用的最新文献。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Crosstalk between tumor and microenvironment: Insights from spatial transcriptomics.

Cancer is a dynamic disease, and clonal heterogeneity plays a fundamental role in tumor development, progression, and resistance to therapies. Single-cell and spatial multimodal technologies can provide a high-resolution molecular map of underlying genomic, epigenomic, and transcriptomic alterations involved in inter- and intra-tumor heterogeneity and interactions with the microenvironment. In this review, we provide a perspective on factors driving cancer heterogeneity, tumor evolution, and clonal states. We briefly describe spatial transcriptomic technologies and summarize recent literature that sheds light on the dynamical interactions between tumor states, cell-to-cell communication, and remodeling local microenvironment.

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