Helena C Maltezou, Flora Sourri, Nikolaos Lemonakis, Amalia Karapanou, Theodoros V Giannouchos, Maria N Gamaletsou, Dimitra-Maria Koukou, Kyriakos Souliotis, Athanasia Lourida, Periklis Panagopoulos, Dimitrios Hatzigeorgiou, Nikolaos V Sipsas
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Patients with respiratory symptoms were grouped either as ILI or as ARI based on the presence of fever, malaise, headache and/or myalgia.</p><p><strong>Results: </strong>Overall, 466 ILI cases and 383 ARI cases occurred. HCP with ILI had an adjusted odds ratio (aOR) of 22.05 [95% confidence interval (CI): 6.23-78.04] to be diagnosed with influenza. HCP with ARI had an aOR of 2.70 (95% CI: 1.88-3.88) to be diagnosed with COVID-19. The sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of ILI for influenza were 96.6%, 49.9%, 18.2%, and 99.2%, respectively. The sensitivity, specificity, PPV, and NPV of ARI for COVID-19 were 51.7%, 73.6%, 84.9%, and 34.8%, respectively. ILI and ARI had an overall correct classification rate of 89.6% and 74.1%, respectively.</p><p><strong>Conclusion: </strong>Our findings support the use of both ILI and ARI case definitions in the diagnosis of influenza and COVID-19 in HCP.</p>","PeriodicalId":94040,"journal":{"name":"Infection, disease & health","volume":" ","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2024-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Evaluation of the influenza-like illness case definition and the acute respiratory infection case definition in the diagnosis of influenza and COVID-19 in healthcare personnel.\",\"authors\":\"Helena C Maltezou, Flora Sourri, Nikolaos Lemonakis, Amalia Karapanou, Theodoros V Giannouchos, Maria N Gamaletsou, Dimitra-Maria Koukou, Kyriakos Souliotis, Athanasia Lourida, Periklis Panagopoulos, Dimitrios Hatzigeorgiou, Nikolaos V Sipsas\",\"doi\":\"10.1016/j.idh.2024.08.002\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>To evaluate the influenza-like illness (ILI) and acute respiratory infection (ARI) case definitions in the diagnosis of COVID-19 and influenza in healthcare personnel (HCP).</p><p><strong>Methods: </strong>We followed a cohort of 5752 HCP from November 2022 to May 2023. Symptomatic HCP were tested for SARS-CoV-2 and influenza by real-time PCR and/or rapid antigen detection test. ILI was defined as the sudden onset of ≥1 systemic symptom and ≥1 respiratory symptom. ARI was defined as the sudden onset of ≥1 respiratory symptom. Patients with respiratory symptoms were grouped either as ILI or as ARI based on the presence of fever, malaise, headache and/or myalgia.</p><p><strong>Results: </strong>Overall, 466 ILI cases and 383 ARI cases occurred. HCP with ILI had an adjusted odds ratio (aOR) of 22.05 [95% confidence interval (CI): 6.23-78.04] to be diagnosed with influenza. HCP with ARI had an aOR of 2.70 (95% CI: 1.88-3.88) to be diagnosed with COVID-19. The sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of ILI for influenza were 96.6%, 49.9%, 18.2%, and 99.2%, respectively. The sensitivity, specificity, PPV, and NPV of ARI for COVID-19 were 51.7%, 73.6%, 84.9%, and 34.8%, respectively. 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引用次数: 0
摘要
背景：评估医护人员在诊断 COVID-19 和流感时对流感样疾病（ILI）和急性呼吸道感染（ARI）病例的定义：评估医护人员（HCP）在诊断COVID-19和流感时的流感样疾病（ILI）和急性呼吸道感染（ARI）病例定义：方法：我们从 2022 年 11 月至 2023 年 5 月对 5752 名医护人员进行了追踪调查。通过实时 PCR 和/或快速抗原检测试验对有症状的医护人员进行了 SARS-CoV-2 和流感检测。ILI定义为突然出现≥1种全身症状和≥1种呼吸道症状。ARI是指突然出现≥1种呼吸道症状。根据发热、乏力、头痛和/或肌痛的存在情况，将有呼吸道症状的患者归为 ILI 或 ARI：总共有 466 例 ILI 和 383 例 ARI。患流感性咽喉炎的住院病人被诊断为流感的调整赔率（aOR）为 22.05 [95%置信区间（CI）：6.23-78.04]。患有急性呼吸道感染的人类接触者被诊断为 COVID-19 的 aOR 为 2.70（95% 置信区间：1.88-3.88）。流感 ILI 的敏感性、特异性、阳性预测值（PPV）和阴性预测值（NPV）分别为 96.6%、49.9%、18.2% 和 99.2%。COVID-19对ARI的敏感性、特异性、PPV和NPV分别为51.7%、73.6%、84.9%和34.8%。ILI和ARI的总体分类正确率分别为89.6%和74.1%：我们的研究结果支持使用 ILI 和 ARI 病例定义来诊断高危人群中的流感和 COVID-19。
Evaluation of the influenza-like illness case definition and the acute respiratory infection case definition in the diagnosis of influenza and COVID-19 in healthcare personnel.
Background: To evaluate the influenza-like illness (ILI) and acute respiratory infection (ARI) case definitions in the diagnosis of COVID-19 and influenza in healthcare personnel (HCP).
Methods: We followed a cohort of 5752 HCP from November 2022 to May 2023. Symptomatic HCP were tested for SARS-CoV-2 and influenza by real-time PCR and/or rapid antigen detection test. ILI was defined as the sudden onset of ≥1 systemic symptom and ≥1 respiratory symptom. ARI was defined as the sudden onset of ≥1 respiratory symptom. Patients with respiratory symptoms were grouped either as ILI or as ARI based on the presence of fever, malaise, headache and/or myalgia.
Results: Overall, 466 ILI cases and 383 ARI cases occurred. HCP with ILI had an adjusted odds ratio (aOR) of 22.05 [95% confidence interval (CI): 6.23-78.04] to be diagnosed with influenza. HCP with ARI had an aOR of 2.70 (95% CI: 1.88-3.88) to be diagnosed with COVID-19. The sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of ILI for influenza were 96.6%, 49.9%, 18.2%, and 99.2%, respectively. The sensitivity, specificity, PPV, and NPV of ARI for COVID-19 were 51.7%, 73.6%, 84.9%, and 34.8%, respectively. ILI and ARI had an overall correct classification rate of 89.6% and 74.1%, respectively.
Conclusion: Our findings support the use of both ILI and ARI case definitions in the diagnosis of influenza and COVID-19 in HCP.
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