橘皮素的神经保护作用

Javeria Fatima, Yasir Hasan Siddique
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引用次数: 0

摘要

随着人们寿命的延长,神经退行性疾病的发病率也在增加,因此有必要探索新型神经保护剂。橘皮素是从柑橘类水果中提取的一种多甲氧基化黄酮,因其潜在的治疗效果而备受关注。本综述将重点介绍橘皮素通过其抗氧化和抗炎机制所具有的神经保护特性。橘皮素在减轻氧化应激、神经炎症和神经元损伤方面具有疗效,适用于各种神经退行性疾病,包括阿尔茨海默病、帕金森病、脑缺血和癫痫。它有望改善与这些疾病相关的认知障碍和记忆损伤。此外,橘皮素还能调节多种信号通路,防止神经元凋亡,这凸显了它作为治疗药物的潜力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The Neuroprotective Role of Tangeritin.

The prevalence of neurodegenerative diseases has increased with longer life expectancies, necessitating the exploration of novel neuroprotective agents. Tangeretin, a polymethoxylated flavone derived from citrus fruits, has gathered attention for its potential therapeutic effects. This review highlights the neuroprotective properties of tangeretin via its antioxidant and anti-inflammatory mechanisms. Tangeretin demonstrates efficacy in mitigating oxidative stress, neuroinflammation, and neuronal damage across various neurodegenerative conditions, including Alzheimer's disease, Parkinson's disease, cerebral ischemia, and epilepsy. It shows promise in ameliorating cognitive deficits and memory impairments associated with these diseases. Moreover, tangeretin modulates multiple signalling pathways and protects against neuronal apoptosis, underscoring its potential as a therapeutic agent.

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