Renad M Alhamawi, Noof Aloufi, Abeer F Alamri, Fatima A Altubayli, Raghad T Alsairi, Reem A Alhamad, Shouq M Alharbi, Zainab A Ankhli, Hamza M A Eid, Yahya A Almutawif
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引用次数: 0
摘要
背景：不变自然杀伤 T 细胞（iNKT）是一种免疫亚群，据称它连接着免疫系统的适应性和先天性臂膀。重要的是，iNKT 细胞能分泌促炎细胞因子，有助于不同类型血液和实体恶性肿瘤的抗癌免疫。因此，利用这类细胞治疗不同类型的肿瘤将是癌症免疫疗法的理想候选方案：评估 iNKT 细胞对不同类型实体瘤和血液肿瘤的预后影响：在系统综述和荟萃分析中，使用Google Scholar、ScienceDirect、PubMed、Cochrane Central和Scopus等科学数据库对评估iNKT细胞预后效应的文章进行了系统检索：结果：令人震惊的是，分析显示瘤内或循环中的iNKT细胞对所有研究肿瘤患者的生存率都有积极影响，总体效应的总危险比为0.89（95% CI 0.81至0.98；P= 0.01）。研究发现，不同肿瘤之间存在高度统计学异质性，I2=87%；P= 0.00001：综上所述，这项研究将为我们提供一个新的视角，让我们了解 iNKT 细胞对癌症患者生存率的影响，以及如何将此类细胞用作这些患者的治疗靶点。
Prognostic impact of invariant natural killer T cells in solid and hematological tumors; systematic review and meta-analysis.
Background: Invariant natural killer T (iNKT) cells are an immune subset that purportedly link the adaptive and the innate arms of the immune system. Importantly, iNKT cells contribute to anti-cancer immunity in different types of hematological and solid malignancies by secreting pro-inflammatory cytokines. Therefore, using such cells in treating different type of tumors would be an ideal candidate for cancer immunotherapy.
Objective: To assess the prognostic effect of iNKT cells across different types of solid and hematological tumors.
Methods: In systematic review and meta-analysis, articles assessed the prognostic effect of iNKT cells were systemically searched using the scientific databases including Google Scholar, ScienceDirect, PubMed, Cochrane Central, and Scopus.
Results: Strikingly, the analysis showed the positive impact of intratumoral or circulating iNKT cells on the survival rate in patients with all studied tumors with overall effect of a pooled hazard ratio of 0.89 (95% CI 0.81 to 0.98; p= 0.01). A highly statistical heterogeneity was noted between studied tumor with I2 = 87%; p= 0.00001.
Conclusions: Taken together, this study would present a new insight into the impact of iNKT cells correlate with caner patients' survival rate and how such cells would be used as a therapeutic target in these patients.
期刊介绍：
Concentrating on molecular biomarkers in cancer research, Cancer Biomarkers publishes original research findings (and reviews solicited by the editor) on the subject of the identification of markers associated with the disease processes whether or not they are an integral part of the pathological lesion.
The disease markers may include, but are not limited to, genomic, epigenomic, proteomics, cellular and morphologic, and genetic factors predisposing to the disease or indicating the occurrence of the disease. Manuscripts on these factors or biomarkers, either in altered forms, abnormal concentrations or with abnormal tissue distribution leading to disease causation will be accepted.
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