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引用次数: 0
摘要
弓形虫病是由弓形虫（Toxoplasma gondii）（Nicolle et Manceaux，1908 年）引起的，它是一种球形原生动物（Apicomplexa）。它极易感染中枢神经系统。因此，研究人员调查了它与几种神经和精神疾病的关系，包括阿尔茨海默病、注意力缺陷多动障碍、自闭症、双相情感障碍、脑瘫、抑郁症、格林-巴利综合征、多发性硬化症、强迫症、帕金森病、人格障碍和精神分裂症。在这些疾病中，最有力的证据表明淋病双球菌在精神病尤其是精神分裂症中的作用。本文回顾了这种关联的起源，简要总结了目前支持这种关联的证据，并讨论了未来的研究策略。
Toxoplasmosis is caused by Toxoplasma gondii (Nicolle et Manceaux, 1908), a coccidian protist (Apicomplexa). It has a strong predilection for infecting the central nervous system. Researchers have therefore investigated its association with several neurological and psychiatric disorders, including Alzheimer's disease, attention-deficit hyperactivity disorder, autism, bipolar disorder, cerebral palsy, depression, Guillain-Barre syndrome, multiple sclerosis, obsessive compulsive disorder, Parkinson's disease, personality disorders, and schizophrenia. Among these disorders the strongest evidence for a role of T. gondii exists for psychosis in general and schizophrenia in particular. This paper reviews the origins of this association, briefly summarises the current evidence in support, and discusses future research strategies.
期刊介绍：
FOLIA PARASITOLOGICA, issued in online versions, is an international journal that covers the whole field of general, systematic, ecological and experimental parasitology. It publishes original research papers, research notes and review articles. Contributions from all branches of animal parasitology, such as morphology, taxonomy, biology, biochemistry, physiology, immunology, molecular biology and evolution of parasites, and host-parasite relationships, are eligible. Novelty and importance in the international (not local or regional) context are required. New geographical records of parasites, records of new hosts, regional parasite and/or host surveys (if they constitute the principal substance of manuscript), local/regional prevalence surveys of diseases, local/regional studies on epidemiology of well known diseases and of parasite impact on human/animal health, case reports, routine clinical studies and testing of established diagnostic or treatment procedures, will not be considered. One species description will also not be considered unless they include more general information, such as new diagnostic characters, host-parasite associations, phylogenetic implications, etc. Manuscripts found suitable on submission will be reviewed by at least two reviewers.
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