利用核特征及血管和囊膜侵犯评估甲状腺肿瘤的诊断难题:一项多中心观察者间一致性研究。

IF 1.7 Q3 PATHOLOGY
Agnes Stephanie Harahap, Mutiah Mutmainnah, Maria Francisca Ham, Dina Khoirunnisa, Abdillah Hasbi Assadyk, Husni Cangara, Aswiyanti Asri, Diah Prabawati Retnani, Fairuz Quzwain, Hasrayati Agustina, Hermawan Istiadi, Indri Windarti, Krisna Murti, Muhammad Takbir, Ni Made Mahastuti, Nila Kurniasari, Nungki Anggorowati, Pamela Abineno, Yulita Pundewi Setyorini, Kennichi Kakudo
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引用次数: 0

摘要

背景:甲状腺肿瘤的诊断需要识别不同的组织学特征。印尼各城市的教育/医院中心各不相同,这很可能导致病理学家在诊断甲状腺肿瘤时意见不一致:本研究考察了印尼病理学家在评估甲状腺肿瘤的核特征、囊性和血管侵犯时的一致性。来自不同中心的 15 位病理学家独立评估了相同的 14 张甲状腺肿瘤标本数字切片。所有标本都是来自一个中心的已知BRAFV600E和RAS突变状态的甲状腺肿瘤。我们使用弗莱斯卡帕评估了培训前后的一致性。使用配对 T 检验评估了培训的显著性:结果:根据三点评分法(k = 0.14 至 0.28)和八点评分法(k = -0.02 至 0.24),核特征的基线一致性为轻微至一般。血管侵犯(κ = 0.35)和囊肿侵犯(κ = 0.27)的一致性一般,而估计的分子类型则显示出很大的一致性(κ = 0.74)。培训后,八分法的一致性明显提高(p = 0.001):结论:印度尼西亚病理学家在诊断甲状腺肿瘤方面的一致性相对较差。结论:印尼病理学家在诊断甲状腺肿瘤方面的一致性相对较差。病理评估方面的共识需要持续的合作和教育来完善诊断标准。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Diagnostic challenges in the assessment of thyroid neoplasms using nuclear features and vascular and capsular invasion: a multi-center interobserver agreement study.

Background: The diagnosis of thyroid neoplasms necessitates the identification of distinct histological features. Various education/hospital centers located in cities across Indonesia likely result in discordances among pathologists when diagnosing thyroid neoplasms.

Methods: This study examined the concordance among Indonesian pathologists in assessing nuclear features and capsular and vascular invasion of thyroid tumors. Fifteen pathologists from different centers independently assessed the same 14 digital slides of thyroid tumor specimens. All the specimens were thyroid neoplasms with known BRAFV600E and RAS mutational status, from a single center. We evaluated the pre- and post-training agreement using the Fleiss kappa. The significance of the training was evaluated using a paired T-test.

Results: Baseline agreement on nuclear features was slight to fair based on a 3-point scoring system (k = 0.14 to 0.28) and poor to fair based on an eight-point system (k = -0.02 to 0.24). Agreements on vascular (κ = 0.35) and capsular invasion (κ = 0.27) were fair, whereas the estimated molecular type showed substantial agreement (κ = 0.74). Following the training, agreement using the eight-point system significantly improved (p = 0.001).

Conclusions: The level of concordance among Indonesian pathologists in diagnosing thyroid neoplasm was relatively poor. Consensus in pathology assessment requires ongoing collaboration and education to refine diagnostic criteria.

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来源期刊
CiteScore
5.00
自引率
4.20%
发文量
45
审稿时长
14 weeks
期刊介绍: The Journal of Pathology and Translational Medicine is an open venue for the rapid publication of major achievements in various fields of pathology, cytopathology, and biomedical and translational research. The Journal aims to share new insights into the molecular and cellular mechanisms of human diseases and to report major advances in both experimental and clinical medicine, with a particular emphasis on translational research. The investigations of human cells and tissues using high-dimensional biology techniques such as genomics and proteomics will be given a high priority. Articles on stem cell biology are also welcome. The categories of manuscript include original articles, review and perspective articles, case studies, brief case reports, and letters to the editor.
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