具有潜在治疗靶点的乳头状肾肿瘤的组织病理学分类和免疫组化特征。

IF 1.7 Q3 PATHOLOGY
Jeong Hwan Park, Su-Jin Shin, Hyun-Jung Kim, Sohee Oh, Yong Mee Cho
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引用次数: 0

摘要

背景:乳头状肾细胞癌(pRCC)是肾细胞癌中第二常见的组织学亚型,被认为是一种形态和分子异质性肿瘤。准确的分类和对可能的治疗靶点的免疫组化特征的评估是精确护理患者所必需的。我们旨在评估乳头状肾肿瘤的免疫组化特征和可能的治疗靶点:我们从三家不同的医院收集了 140 例乳头状肾肿瘤,并对组织芯片切片进行了免疫组化研究。我们对琥珀酸脱氢酶 B、富马酸氢化酶和转录因子 E3 进行了免疫组化研究以进行鉴别诊断,并对 5 例(3.6%)乳头状肾肿瘤进行了重新分类。此外,我们还进行了 c-MET、p16、c-Myc、Ki-67、p53 和干扰素基因刺激因子(STING)免疫组化研究,以评估其发病机制和治疗靶点价值:我们发现,在乳头状肾肿瘤中,c-MET的表达在pRCC(典型)中更为常见(p = .021),与pRCC(典型)和极性相反的乳头状肿瘤相比,pRCC(未另作规定,NOS)的Ki-67增殖指数更高(边缘显著性,p = .080)。小部分病例存在 p16 阻滞阳性(4.5%)(仅 pRCC [NOS])和 c-Myc 表达(7.1%)(仅 pRCC [典型])。此外,还有一些病例显示 STING 表达,这些病例与 Ki-67 增殖指数升高有关(边缘显著性,p = .063):我们的研究结果表明,pRCC 中存在表达 c-MET、p16、c-MYC 和 STING 的亚群,这些病例可能成为靶向治疗的潜在候选者。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Histopathologic classification and immunohistochemical features of papillary renal neoplasm with potential therapeutic targets.

Background: Papillary renal cell carcinoma (pRCC) is the second most common histological subtype of renal cell carcinoma and is considered a morphologically and molecularly heterogeneous tumor. Accurate classification and assessment of the immunohistochemical features of possible therapeutic targets are needed for precise patient care. We aimed to evaluate immunohistochemical features and possible therapeutic targets of papillary renal neoplasms.

Methods: We collected 140 papillary renal neoplasms from three different hospitals and conducted immunohistochemical studies on tissue microarray slides. We performed succinate dehydrogenase B, fumarate hydratase, and transcription factor E3 immunohistochemical studies for differential diagnosis and re-classified five cases (3.6%) of papillary renal neoplasms. In addition, we conducted c-MET, p16, c-Myc, Ki-67, p53, and stimulator of interferon genes (STING) immunohistochemical studies to evaluate their pathogenesis and value for therapeutic targets.

Results: We found that c-MET expression was more common in pRCC (classic) (p = .021) among papillary renal neoplasms and Ki-67 proliferation index was higher in pRCC (not otherwise specified, NOS) compared to that of pRCC (classic) and papillary neoplasm with reverse polarity (marginal significance, p = .080). Small subsets of cases with p16 block positivity (4.5%) (pRCC [NOS] only) and c-Myc expression (7.1%) (pRCC [classic] only) were found. Also, there were some cases showing STING expression and those cases were associated with increased Ki-67 proliferation index (marginal significance, p = .063).

Conclusions: Our findings suggested that there are subsets of pRCC with c-MET, p16, c-MYC, and STING expression and those cases could be potential candidates for targeted therapy.

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来源期刊
CiteScore
5.00
自引率
4.20%
发文量
45
审稿时长
14 weeks
期刊介绍: The Journal of Pathology and Translational Medicine is an open venue for the rapid publication of major achievements in various fields of pathology, cytopathology, and biomedical and translational research. The Journal aims to share new insights into the molecular and cellular mechanisms of human diseases and to report major advances in both experimental and clinical medicine, with a particular emphasis on translational research. The investigations of human cells and tissues using high-dimensional biology techniques such as genomics and proteomics will be given a high priority. Articles on stem cell biology are also welcome. The categories of manuscript include original articles, review and perspective articles, case studies, brief case reports, and letters to the editor.
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