癌症相关微肽鉴定中的多肽方法

IF 4 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY
Katarina Vrbnjak, Raj Nayan Sewduth
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引用次数: 0

摘要

尽管现代癌症治疗技术不断进步,但恶性肿瘤仍然是全球发病率和死亡率的主要原因。传统的治疗方法经常会导致副作用和患者产生耐药性,这凸显了对新型治疗方法的需求。最近的研究发现了非典型微肽的存在,它们是蛋白质组复杂性的另一层,也被称为微蛋白质组。这些小肽是一类很有前景的治疗药物,有可能解决目前癌症治疗的局限性。微蛋白组由基因组中历来被注释为非编码的区域编码,由于蛋白质组学和生物信息学技术的最新进展,人们对蛋白质组复杂性的认识有了极大的提高,微蛋白组的存在才得以揭示。微肽已被证明在几种癌症类型中具有生物活性,这表明了它们的治疗作用。此外,它们还具有低毒性和高靶向特异性的特点,这表明它们具有开发耐受性更好的药物的潜力。在这篇综述中,我们调查了目前已知的在癌症进展或治疗中发挥作用的微肽的情况,讨论了它们作为抗癌药物的潜力,并描述了蛋白质组研究领域所面临的方法学挑战。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Multi-Omic Approaches in Cancer-Related Micropeptide Identification.

Despite the advances in modern cancer therapy, malignant diseases are still a leading cause of morbidity and mortality worldwide. Conventional treatment methods frequently lead to side effects and drug resistance in patients, highlighting the need for novel therapeutic approaches. Recent findings have identified the existence of non-canonical micropeptides, an additional layer of the proteome complexity, also called the microproteome. These small peptides are a promising class of therapeutic agents with the potential to address the limitations of current cancer treatments. The microproteome is encoded by regions of the genome historically annotated as non-coding, and its existence has been revealed thanks to recent advances in proteomic and bioinformatic technology, which dramatically improved the understanding of proteome complexity. Micropeptides have been shown to be biologically active in several cancer types, indicating their therapeutic role. Furthermore, they are characterized by low toxicity and high target specificity, demonstrating their potential for the development of better tolerated drugs. In this review, we survey the current landscape of known micropeptides with a role in cancer progression or treatment, discuss their potential as anticancer agents, and describe the methodological challenges facing the proteome field of research.

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来源期刊
Proteomes
Proteomes Biochemistry, Genetics and Molecular Biology-Clinical Biochemistry
CiteScore
6.50
自引率
3.00%
发文量
37
审稿时长
11 weeks
期刊介绍: Proteomes (ISSN 2227-7382) is an open access, peer reviewed journal on all aspects of proteome science. Proteomes covers the multi-disciplinary topics of structural and functional biology, protein chemistry, cell biology, methodology used for protein analysis, including mass spectrometry, protein arrays, bioinformatics, HTS assays, etc. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. Therefore, there is no restriction on the length of papers. Scope: -whole proteome analysis of any organism -disease/pharmaceutical studies -comparative proteomics -protein-ligand/protein interactions -structure/functional proteomics -gene expression -methodology -bioinformatics -applications of proteomics
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