高组蛋白 H3K18 乳化水平与上皮性卵巢癌的不良预后相关。

IF 2 4区 医学 Q3 ONCOLOGY
Jinyu Chao, Guan-di Chen, Shu-Ting Huang, Haifeng Gu, Yue-Yang Liu, Yiheng Luo, Zidan Lin, Zhi-Zai Chen, Xiaoli Li, Bin Zhang, Xifeng Xu, Shanyang He
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引用次数: 0

摘要

蛋白质乳化在恶性肿瘤中预后较差,但它对上皮性卵巢癌(EOC)预后的影响仍不清楚。我们对 112 例 EOC 患者进行了分析。免疫组化染色法检测了EOC组织和正常卵巢组织中泛乳化(Pan Kla)和组蛋白H3K18乳化(H3K18la)的水平。结果显示,EOC组织的蛋白乳化水平高于正常组织。然后,我们分析了EOC的总生存期(OS)、无进展生存期(PFS)与乳酸化之间的关系。结果显示,组蛋白H3K18la水平高的患者OS(P=0.028)和PFS(P=0.028)均较差。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
High histone H3K18 lactylation level is correlated with poor prognosis in epithelial ovarian cancer.

Protein lactylation has a poor prognosis in malignant tumors, but its impact on the prognosis of epithelial ovarian cancer (EOC) remains unknown. We analyzed 112 patients with EOC. Immunohistochemical staining was used to detect the level of pan lactylation (Pan Kla) and histone H3K18 lactylation (H3K18la) in the EOC tissues and normal ovarian tissues. The result showed that the protein lactylation level in EOC was higher than in normal tissues. Then, we analyzed the relationship between overall survival (OS), progression-free survival (PFS) of EOC, and lactylation. The result showed that patients with high histone H3K18la levels had poorer OS (p=0.028) and PFS (p<0.001). Multivariate Cox regression analysis of PFS showed histone H3K18la was an independent risk factor (p=0.001). In addition, we found that both histone H3K18la and Pan Kla in the cytoplasm were associated with platinum recurrence time (p=0.002/p=0.003). The results also indicated that the H3K18la level was related to a tumor stage (p=0.037). Furthermore, we explored the effects of lactylation on the metastasis of ovarian cancer. The results indicated a significant increase in migration in the promoter group compared to the negative control group and inhibitor group. In conclusion, high histone H3K18la level is associated with poor prognosis in EOC. Protein lactylation may have a significant impact on EOC and could potentially be used as a target for EOC therapy in the future.

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来源期刊
Neoplasma
Neoplasma 医学-肿瘤学
CiteScore
5.40
自引率
0.00%
发文量
238
审稿时长
3 months
期刊介绍: The journal Neoplasma publishes articles on experimental and clinical oncology and cancer epidemiology.
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