散发性克雅氏病的系统回顾:发病机制、诊断和治疗尝试。

IF 3.2 Q2 CLINICAL NEUROLOGY
Maria Carolina Jurcau, Anamaria Jurcau, Razvan Gabriel Diaconu, Vlad Octavian Hogea, Vharoon Sharma Nunkoo
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引用次数: 0

摘要

克雅氏病是一种罕见的神经退行性疾病,一旦出现最初的临床症状,其病程必然是致命的。该病的发病率似乎正在上升,尽管数字的上升可能与诊断工具的改进有关。由于发病时的临床表现千变万化,许多专科医生都应了解这种疾病,并将患者转诊至神经科医生进行全面评估。随着发病机制研究的深入和可靠生物标志物的确定,诊断标准也发生了变化。此外,对发病机理的知识积累还导致确定了一系列可能的治疗靶点,不过,由于发病率低且病程非常迅速,对这些治疗策略的安全性和有效性进行评估具有挑战性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
A Systematic Review of Sporadic Creutzfeldt-Jakob Disease: Pathogenesis, Diagnosis, and Therapeutic Attempts.

Creutzfeldt-Jakob disease is a rare neurodegenerative and invariably fatal disease with a fulminant course once the first clinical symptoms emerge. Its incidence appears to be rising, although the increasing figures may be related to the improved diagnostic tools. Due to the highly variable clinical picture at onset, many specialty physicians should be aware of this disease and refer the patient to a neurologist for complete evaluation. The diagnostic criteria have been changed based on the considerable progress made in research on the pathogenesis and on the identification of reliable biomarkers. Moreover, accumulated knowledge on pathogenesis led to the identification of a series of possible therapeutic targets, although, given the low incidence and very rapid course, the evaluation of safety and efficacy of these therapeutic strategies is challenging.

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来源期刊
Neurology International
Neurology International CLINICAL NEUROLOGY-
CiteScore
3.70
自引率
3.30%
发文量
69
审稿时长
11 weeks
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