利用无线核磁共振标记和超短回波导航仪在 3 特斯拉条件下进行前瞻性头部运动校正。

IF 2.1 4区医学 Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Magnetic resonance imaging Pub Date : 2024-09-12 DOI:10.1016/j.mri.2024.110238

Saikat Sengupta , Antonio Glenn , Baxter P. Rogers

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引用次数: 0

摘要

目的：使用电感耦合无线核磁共振标记物进行前瞻性运动校正（PMC）已被证明是在 7 特斯拉条件下处理头部运动的一种有效的即插即用方法[29,30]。然而，技术上的挑战，如三个无线标记的一对一识别、高强度标记伪影的产生以及导航仪中标记峰值 SNR 的降低，限制了这一技术的应用。这项工作的目标是介绍克服这些问题的解决方案，并将该技术扩展到 3 特斯拉下的脑成像 PMC：方法：使用新颖的 ∼8 ms 超短回波时间 (UTE) 导航仪，配合优化选择的氯化锰标记样本，实现了具有 6 个自由度 (DOF) 的 PMC，以最大限度地减少标记伪影。利用不同的头部线圈灵敏度来识别和跟踪单个标记物，并采用可变翻转角（VFA）方案和实时滤波来提高标记物信噪比。在成年志愿者自愿头部运动的情况下，在 3 特斯拉的三维 T1 加权脑成像中进行了 PMC：结果：在所有受试者的三维 T1 加权成像中，与类似运动的非运动校正图像相比，使用无线标记的 PMC 提高了图像质量，而且没有明显的标记伪影。运动追踪的精确度在 0.01-0.06 毫米/度之间。导航仪的执行对序列持续时间的影响极小：无线 NMR 标记为不同场强的脑成像中的 6 DOF PMC 提供了准确、无需校准且经济的选择。这项技术所面临的挑战可通过结合导航仪设计、样本选择和实时数据处理策略来解决。

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Prospective head motion correction at 3 Tesla with wireless NMR markers and ultrashort echo navigators

Purpose

Prospective motion correction (PMC) with inductively-coupled wireless NMR markers has been shown to be an effective plug-and-play method for dealing with head motion at 7 Tesla [29,30]. However, technical challenges such as one-to-one identification of three wireless markers, generation of hyper-intense marker artifacts and low marker peak SNR in the navigators has limited the adoption of this technique. The goal of this work is to introduce solutions to overcome these issues and extend this technique to PMC for brain imaging at 3 Tesla.

Methods

PMC with 6 degrees of freedom (DOF) was implemented using a novel ∼8 ms, ultrashort echo time (UTE) navigator in concert with optimally chosen MnCl₂ marker samples to minimize marker artifacts. Distinct head coil sensitivities were leveraged to enable identification and tracking of individual markers and a variable flip angle (VFA) scheme and real time filtering were used to boost marker SNR. PMC was performed in 3D T₁ weighted brain imaging at 3 Tesla with voluntary head motions in adult volunteers.

Results

PMC with wireless markers improved image quality in 3D T₁ weighted images in all subjects compared to non-motion corrected images for similar motions with no noticeable marker artifacts. Precision of motion tracking was found to be in the range of 0.01–0.06 mm/degrees. Navigator execution had minimal impact on sequence duration.

Conclusions

Wireless NMR markers provide an accurate, calibration-free and economical option for 6 DOF PMC in brain imaging across field strengths. Challenges in this technique can be addressed by combining navigator design, sample selection and real time data processing strategies.

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来源期刊

Magnetic resonance imaging 医学-核医学

CiteScore

4.70

自引率

4.00%

发文量

194

审稿时长

83 days

期刊介绍： Magnetic Resonance Imaging (MRI) is the first international multidisciplinary journal encompassing physical, life, and clinical science investigations as they relate to the development and use of magnetic resonance imaging. MRI is dedicated to both basic research, technological innovation and applications, providing a single forum for communication among radiologists, physicists, chemists, biochemists, biologists, engineers, internists, pathologists, physiologists, computer scientists, and mathematicians.