可见光照射的变化可调节血小板功能并调节血栓的形成。

IF 5.5 2区医学 Q1 HEMATOLOGY

Journal of Thrombosis and Haemostasis Pub Date : 2024-09-17 DOI:10.1016/j.jtha.2024.08.020

Elizabeth A Andraska, Frederik Denorme, Christof Kaltenmeier, Aishwarrya Arivudainabi, Emily P Mihalko, Mitchell Dyer, Gowtham K Annarapu, Mohammadreza Zarisfi, Patricia Loughran, Mehves Ozel, Kelly Williamson, Roberto Mota-Alvidrez, Kimberly Thomas, Sruti Shiva, Susan Shea, Richard A Steinman, Robert A Campbell, Matthew R Rosengart, Matthew D Neal

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引用次数: 0

摘要

背景：光照射的变化与炎症和凝血的变化有关。光谱对静脉（VT）和动脉血栓形成的影响在很大程度上尚未得到研究：研究改变光谱对血栓形成中血小板功能的影响：方法：将野生型（WT）C57BL/6J小鼠暴露在环境光（micewhite，400lux）、蓝光（miceblue，442nm，1,400lux）或红光（micered，617nm，1,400lux）下72小时，光暗周期为12:12小时。光照 72 小时后，测量血小板聚集、活化、转录组和代谢组的变化。对血小板活化释放的产物诱导血栓形成的能力进行了量化。随后利用小鼠 VT 和中风模型对血栓形成进行了测定。为了将我们的研究结果应用于人类患者，我们对滤光性白内障患者进行了为期 8 年的 VTE 发生率评估，并按医院进行了多变量逻辑回归：结果：暴露于长波长红光可减少血小板聚集和活化。RNA-seq分析表明，微红光和微白光之间没有明显的转录组变化。然而，与小鼠白细胞相比，红细胞血小板的代谢组发生了整体变化。活化血小板的释放物减少了 NET 的形成。小鼠ered在中风后的VT重量和脑梗塞面积也有所减少。在对白内障患者进行的亚组分析中，有癌症病史的患者在植入过滤低波长光的镜片后，终生发生 VTE 的风险较低：结论：光疗可专门针对先天性免疫功能和凝血功能之间的交叉点，是一种很有前景的血栓预防方法。

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TEMPORARY REMOVAL: Alterations in visible light exposure modulate platelet function and regulate thrombus formation.

The publisher regrets that this article has been temporarily removed. A replacement will appear as soon as possible in which the reason for the removal of the article will be specified, or the article will be reinstated. The full Elsevier Policy on Article Withdrawal can be found at: https://www.elsevier.com/about/policies/article-withdrawal.

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来源期刊

Journal of Thrombosis and Haemostasis 医学-外周血管病

CiteScore

24.30

自引率

3.80%

发文量

321

审稿时长

1 months

期刊介绍： The Journal of Thrombosis and Haemostasis (JTH) serves as the official journal of the International Society on Thrombosis and Haemostasis. It is dedicated to advancing science related to thrombosis, bleeding disorders, and vascular biology through the dissemination and exchange of information and ideas within the global research community. Types of Publications: The journal publishes a variety of content, including: Original research reports State-of-the-art reviews Brief reports Case reports Invited commentaries on publications in the Journal Forum articles Correspondence Announcements Scope of Contributions: Editors invite contributions from both fundamental and clinical domains. These include: Basic manuscripts on blood coagulation and fibrinolysis Studies on proteins and reactions related to thrombosis and haemostasis Research on blood platelets and their interactions with other biological systems, such as the vessel wall, blood cells, and invading organisms Clinical manuscripts covering various topics including venous thrombosis, arterial disease, hemophilia, bleeding disorders, and platelet diseases Clinical manuscripts may encompass etiology, diagnostics, prognosis, prevention, and treatment strategies.