洞察脂肪细胞去分化的分子变化及其未来研究机会。

IF 5 2区医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Journal of Lipid Research Pub Date : 2024-09-18 DOI:10.1016/j.jlr.2024.100644

Mingheng Xue, Yunjun Liao, Wenqing Jiang

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引用次数: 0

摘要

最近的研究挑战了成熟脂肪细胞不可逆转分化的传统观念，发现它们可以再分化成纤维母细胞样细胞，即再分化脂肪细胞（DFAT）。DFAT 细胞与多能干细胞相似，具有作为干细胞疗法细胞来源的巨大潜力。然而，人们对脂肪细胞去分化后发生的具体变化以及这一过程的详细调控了解有限。这篇综述探讨了与DFAT细胞去分化相关的表观遗传学、基因和表型改变，确定了临床调控的潜在靶点，并讨论了目前DFAT细胞研究领域的应用和挑战。

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Insights into the molecular changes of adipocyte dedifferentiation and its future research opportunities.

Recent studies have challenged the traditional belief that mature fat cells are irreversibly differentiated and revealed they can dedifferentiate into fibroblast-like cells known as dedifferentiated fat (DFAT) cells. Resembling pluripotent stem cells, DFAT cells hold great potential as a cell source for stem cell therapy. However, there is limited understanding of the specific changes that occur following adipocyte dedifferentiation and the detailed regulation of this process. This review explores the epigenetic, genetic, and phenotypic alterations associated with DFAT cell dedifferentiation, identifies potential targets for clinical regulation and discusses the current applications and challenges in the field of DFAT cell research.

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来源期刊

Journal of Lipid Research 生物-生化与分子生物学

CiteScore

11.10

自引率

4.60%

发文量

146

审稿时长

41 days

期刊介绍： The Journal of Lipid Research (JLR) publishes original articles and reviews in the broadly defined area of biological lipids. We encourage the submission of manuscripts relating to lipids, including those addressing problems in biochemistry, molecular biology, structural biology, cell biology, genetics, molecular medicine, clinical medicine and metabolism. Major criteria for acceptance of articles are new insights into mechanisms of lipid function and metabolism and/or genes regulating lipid metabolism along with sound primary experimental data. Interpretation of the data is the authors’ responsibility, and speculation should be labeled as such. Manuscripts that provide new ways of purifying, identifying and quantifying lipids are invited for the Methods section of the Journal. JLR encourages contributions from investigators in all countries, but articles must be submitted in clear and concise English.