Catriona M Farrell, Giacomo Cappon, Daniel J West, Andrea Facchinetti, Rory J McCrimmon
{"title":"HIT4HYPOS 连续血糖监测数据分析：高强度间歇训练对 1 型糖尿病患者和低血糖意识受损者低血糖的影响。","authors":"Catriona M Farrell, Giacomo Cappon, Daniel J West, Andrea Facchinetti, Rory J McCrimmon","doi":"10.1177/19322968241273845","DOIUrl":null,"url":null,"abstract":"<p><strong>Aims: </strong>To assess the impact of high-intensity interval training (HIIT) on hypoglycemia frequency and duration in people with type 1 diabetes (T1D) with impaired awareness of hypoglycemia (IAH).</p><p><strong>Methods: </strong>Post hoc analysis of four weeks of continuous glucose monitoring (CGM) data from HIT4HYPOS; a parallel-group study comparing HIIT + CGM versus no exercise + CGM in 18 participants with T1D and IAH.</p><p><strong>Results: </strong>When compared with those participating individuals not exercising, HIIT did not increase total hypoglycemia frequency, <i>T<sub>Hypo(L1)</sub></i> 1.44 [1.00-2.77]% versus 2.53 [1.46-4.23]%; <i>P</i> = .335, <i>T<sub>Hypo(L2)</sub></i> 0.25 [0.09-0.37]% versus 0.45 [0.20-0.78]%; <i>P</i> = .146, HIIT + CGM versus CGM, respectively, rate (<i>EventPerWeek<sub>Hypo</sub></i> 5.30 [3.35-8.27] #/week vs 7.45 [3.54-10.81] #/week, <i>P</i> = .340) or duration (<i>Duration<sub>Hypo</sub></i> 33.33 [27.60-39.10] minutes vs 39.56 [31.00-48.38] minutes; <i>P</i> = .219, HIIT + CGM vs CGM, respectively). There was a reduction in nocturnal hypoglycemia in those who carried out HIIT, <i>T<sub>Hypo</sub></i><sub>(L1)</sub> 0.50 [0.13-0.97]% versus 2.45 [0.77-4.74]%; <i>P</i> = .076; <i>T<sub>Hypo</sub></i><sub>(L2)</sub> 0.00 [0.00-0.03]% versus 0.49 [0.13-0.74]%; <i>P</i> = .006, HIIT + CGM versus CGM, respectively.</p><p><strong>Conclusions/interpretation: </strong>Based on CGM data collected from a real-world study of four weeks of HIIT versus no exercise in individuals with T1D and IAH, we conclude that HIIT does not increase hypoglycemia, and in fact reduces exposure to nocturnal hypoglycemia.</p>","PeriodicalId":15475,"journal":{"name":"Journal of Diabetes Science and Technology","volume":" ","pages":"19322968241273845"},"PeriodicalIF":4.1000,"publicationDate":"2024-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11571604/pdf/","citationCount":"0","resultStr":"{\"title\":\"HIT4HYPOS Continuous Glucose Monitoring Data Analysis: The Effects of High-Intensity Interval Training on Hypoglycemia in People With Type 1 Diabetes and Impaired Awareness of Hypoglycemia.\",\"authors\":\"Catriona M Farrell, Giacomo Cappon, Daniel J West, Andrea Facchinetti, Rory J McCrimmon\",\"doi\":\"10.1177/19322968241273845\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Aims: </strong>To assess the impact of high-intensity interval training (HIIT) on hypoglycemia frequency and duration in people with type 1 diabetes (T1D) with impaired awareness of hypoglycemia (IAH).</p><p><strong>Methods: </strong>Post hoc analysis of four weeks of continuous glucose monitoring (CGM) data from HIT4HYPOS; a parallel-group study comparing HIIT + CGM versus no exercise + CGM in 18 participants with T1D and IAH.</p><p><strong>Results: </strong>When compared with those participating individuals not exercising, HIIT did not increase total hypoglycemia frequency, <i>T<sub>Hypo(L1)</sub></i> 1.44 [1.00-2.77]% versus 2.53 [1.46-4.23]%; <i>P</i> = .335, <i>T<sub>Hypo(L2)</sub></i> 0.25 [0.09-0.37]% versus 0.45 [0.20-0.78]%; <i>P</i> = .146, HIIT + CGM versus CGM, respectively, rate (<i>EventPerWeek<sub>Hypo</sub></i> 5.30 [3.35-8.27] #/week vs 7.45 [3.54-10.81] #/week, <i>P</i> = .340) or duration (<i>Duration<sub>Hypo</sub></i> 33.33 [27.60-39.10] minutes vs 39.56 [31.00-48.38] minutes; <i>P</i> = .219, HIIT + CGM vs CGM, respectively). There was a reduction in nocturnal hypoglycemia in those who carried out HIIT, <i>T<sub>Hypo</sub></i><sub>(L1)</sub> 0.50 [0.13-0.97]% versus 2.45 [0.77-4.74]%; <i>P</i> = .076; <i>T<sub>Hypo</sub></i><sub>(L2)</sub> 0.00 [0.00-0.03]% versus 0.49 [0.13-0.74]%; <i>P</i> = .006, HIIT + CGM versus CGM, respectively.</p><p><strong>Conclusions/interpretation: </strong>Based on CGM data collected from a real-world study of four weeks of HIIT versus no exercise in individuals with T1D and IAH, we conclude that HIIT does not increase hypoglycemia, and in fact reduces exposure to nocturnal hypoglycemia.</p>\",\"PeriodicalId\":15475,\"journal\":{\"name\":\"Journal of Diabetes Science and Technology\",\"volume\":\" \",\"pages\":\"19322968241273845\"},\"PeriodicalIF\":4.1000,\"publicationDate\":\"2024-09-23\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11571604/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Diabetes Science and Technology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1177/19322968241273845\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"ENDOCRINOLOGY & METABOLISM\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Diabetes Science and Technology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1177/19322968241273845","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"ENDOCRINOLOGY & METABOLISM","Score":null,"Total":0}
HIT4HYPOS Continuous Glucose Monitoring Data Analysis: The Effects of High-Intensity Interval Training on Hypoglycemia in People With Type 1 Diabetes and Impaired Awareness of Hypoglycemia.
Aims: To assess the impact of high-intensity interval training (HIIT) on hypoglycemia frequency and duration in people with type 1 diabetes (T1D) with impaired awareness of hypoglycemia (IAH).
Methods: Post hoc analysis of four weeks of continuous glucose monitoring (CGM) data from HIT4HYPOS; a parallel-group study comparing HIIT + CGM versus no exercise + CGM in 18 participants with T1D and IAH.
Results: When compared with those participating individuals not exercising, HIIT did not increase total hypoglycemia frequency, THypo(L1) 1.44 [1.00-2.77]% versus 2.53 [1.46-4.23]%; P = .335, THypo(L2) 0.25 [0.09-0.37]% versus 0.45 [0.20-0.78]%; P = .146, HIIT + CGM versus CGM, respectively, rate (EventPerWeekHypo 5.30 [3.35-8.27] #/week vs 7.45 [3.54-10.81] #/week, P = .340) or duration (DurationHypo 33.33 [27.60-39.10] minutes vs 39.56 [31.00-48.38] minutes; P = .219, HIIT + CGM vs CGM, respectively). There was a reduction in nocturnal hypoglycemia in those who carried out HIIT, THypo(L1) 0.50 [0.13-0.97]% versus 2.45 [0.77-4.74]%; P = .076; THypo(L2) 0.00 [0.00-0.03]% versus 0.49 [0.13-0.74]%; P = .006, HIIT + CGM versus CGM, respectively.
Conclusions/interpretation: Based on CGM data collected from a real-world study of four weeks of HIIT versus no exercise in individuals with T1D and IAH, we conclude that HIIT does not increase hypoglycemia, and in fact reduces exposure to nocturnal hypoglycemia.
期刊介绍：
The Journal of Diabetes Science and Technology (JDST) is a bi-monthly, peer-reviewed scientific journal published by the Diabetes Technology Society. JDST covers scientific and clinical aspects of diabetes technology including glucose monitoring, insulin and metabolic peptide delivery, the artificial pancreas, digital health, precision medicine, social media, cybersecurity, software for modeling, physiologic monitoring, technology for managing obesity, and diagnostic tests of glycation. The journal also covers the development and use of mobile applications and wireless communication, as well as bioengineered tools such as MEMS, new biomaterials, and nanotechnology to develop new sensors. Articles in JDST cover both basic research and clinical applications of technologies being developed to help people with diabetes.
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