Agnieszka Jankowska, Maja Ścieszko, Alicja Polańska, Alexandra Jerzyńska, Jolanta Dominowska, Agnieszka Brzozowska
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Ultimately, the review analyzed 25 articles including 16 that assessed the effects of prenatal exposure to pyrethroids on children's neurobehavioural development, 3 studies that assessed the effects on the course and outcome of pregnancy, and further 3 focused on respiratory disease. In addition, 1 study analyzed the development of obesity and 2 studies examined the effects on children's growth, weight and body composition in early childhood. In conclusion, there is considerable uncertainty about the adverse effects of prenatal exposure to pyrethroids on children's health. The strongest evidence has been reported for neurobehavioural development although results are also inconsistent. Further research is needed to understand the mechanisms of action and health effects of pyrethroids in susceptible populations. 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引用次数: 0
摘要
拟除虫菊酯是一种广泛应用于农业、林业和家庭的杀虫剂,由于其对儿童健康的潜在影响,拟除虫菊酯的暴露已成为一个重大的公共卫生问题。本综述旨在总结产前接触拟除虫菊酯对妊娠过程和结果、儿童健康状况和神经行为发育影响的现有知识。2024 年 1 月至 2 月期间,对 PubMed、Web of Science 和 Scopus 数据库进行了系统而全面的检索。综述包括自 2015 年以来在同行评审的英文期刊上发表的原创文章。根据关键词确定了 198 项研究,并进行了资格筛选。最终,综述分析了 25 篇文章,其中 16 篇评估了产前接触拟除虫菊酯对儿童神经行为发育的影响,3 篇评估了对妊娠过程和结果的影响,另外 3 篇侧重于呼吸系统疾病。此外,1 项研究分析了肥胖症的发展,2 项研究探讨了对幼儿期儿童生长、体重和身体成分的影响。总之,产前接触拟除虫菊酯对儿童健康的不良影响还存在很大的不确定性。最有力的证据是关于神经行为发育的报告,尽管结果也不一致。要了解除虫菊酯对易感人群的作用机制和健康影响,还需要进一步的研究。Int J Occup Med Environ Health.2024;37(4).
The association between prenatal pyrethroids exposure and children's health - current research.
Exposure to pyrethroids, a widely used agricultural, forestry, and household insecticide, is a major public health concern due to its potential health effects on children. The aim of this review was to summarize the current knowledge of the effects of prenatal exposure to pyrethroids on the course and outcome of pregnancy, health status, and neurobehavioural development of children. A systematic and comprehensive search of the PubMed, Web of Science, and Scopus databases was conducted during January-February 2024. The review included original articles published in peerreviewed English-language journals since 2015. Based on keywords, 198 studies were identified and screened for eligibility. Ultimately, the review analyzed 25 articles including 16 that assessed the effects of prenatal exposure to pyrethroids on children's neurobehavioural development, 3 studies that assessed the effects on the course and outcome of pregnancy, and further 3 focused on respiratory disease. In addition, 1 study analyzed the development of obesity and 2 studies examined the effects on children's growth, weight and body composition in early childhood. In conclusion, there is considerable uncertainty about the adverse effects of prenatal exposure to pyrethroids on children's health. The strongest evidence has been reported for neurobehavioural development although results are also inconsistent. Further research is needed to understand the mechanisms of action and health effects of pyrethroids in susceptible populations. Int J Occup Med Environ Health. 2024;37(4):381-402.
期刊介绍:
The Journal is dedicated to present the contemporary research in occupational and environmental health from all over the world. It publishes works concerning: occupational and environmental: medicine, epidemiology, hygiene and toxicology; work physiology and ergonomics, musculoskeletal problems; psychosocial factors at work, work-related mental problems, aging, work ability and return to work; working hours, shift work; reproductive factors and endocrine disruptors; radiation, ionizing and non-ionizing health effects; agricultural hazards; work safety and injury and occupational health service; climate change and its effects on health; omics, genetics and epigenetics in occupational and environmental health; health effects of exposure to nanoparticles and nanotechnology products; human biomarkers in occupational and environmental health, intervention studies, clinical sciences’ achievements with potential to improve occupational and environmental health.