对 PFKFB3 介导的糖酵解在肝纤维化中的作用和作用机制的认识取得进展(综述)。

IF 5.7 3区 医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL
International journal of molecular medicine Pub Date : 2024-12-01 Epub Date: 2024-09-20 DOI:10.3892/ijmm.2024.5429
Qian Liu, Jiajia Li, Xin Li, Li Zhang, Shun Yao, Yongfeng Wang, Biguang Tuo, Hai Jin
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引用次数: 0

摘要

肝纤维化是慢性肝病的一种病理生理表现,也是肝硬化和肝细胞癌的前兆。糖酵解为肝纤维中的细胞增殖和表型转化提供中间代谢产物和能量支持。6-磷酸果糖-2-激酶/果糖-2,6-二磷酸酶 3(PFKFB3)是糖酵解的关键激活剂,在糖酵解过程中发挥着重要作用。PFKFB3 介导的糖酵解在心肌纤维化、肾脏纤维化和肺纤维化中的作用已被证实,PFKFB3 在有氧糖酵解激活肝星状细胞中的作用也已被相关实验证实。本研究回顾了PFKFB3介导的糖酵解在肝纤维化进展中的作用及作用机制的研究进展,探讨了PFKFB3介导的糖酵解在肝纤维化中的作用,为PFKFB3作为肝纤维化治疗靶点的研究提供了新思路。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Advances in the understanding of the role and mechanism of action of PFKFB3‑mediated glycolysis in liver fibrosis (Review).

Liver fibrosis is a pathophysiologic manifestation of chronic liver disease and a precursor to cirrhosis and hepatocellular carcinoma. Glycolysis provides intermediate metabolites as well as energy support for cell proliferation and phenotypic transformation in liver fibers. 6‑Phosphofructo‑2‑kinase/fructose‑2,6‑bisphosphatase 3 (PFKFB3) is a key activator of glycolysis and plays an important role in the process of glycolysis. The role of PFKFB3‑mediated glycolysis in myocardial fibrosis, renal fibrosis and pulmonary fibrosis has been demonstrated, and the role of PFKFB3 in the activation of hepatic stellate cells by aerobic glycolysis has been proven by relevant experiments. The present study reviews the research progress on the role and mechanism of action of PFKFB3‑mediated glycolysis in the progression of hepatic fibrosis to discuss the role of PFKFB3‑mediated glycolysis in hepatic fibrosis and to provide new ideas for research on PFKFB3 as a target for the treatment of hepatic fibrosis.

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来源期刊
International journal of molecular medicine
International journal of molecular medicine 医学-医学:研究与实验
CiteScore
12.30
自引率
0.00%
发文量
124
审稿时长
3 months
期刊介绍: The main aim of Spandidos Publications is to facilitate scientific communication in a clear, concise and objective manner, while striving to provide prompt publication of original works of high quality. The journals largely concentrate on molecular and experimental medicine, oncology, clinical and experimental cancer treatment and biomedical research. All journals published by Spandidos Publications Ltd. maintain the highest standards of quality, and the members of their Editorial Boards are world-renowned scientists.
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