胶质瘤相关小胶质细胞/巨噬细胞的脂质代谢重构(综述)。

IF 5.7 3区 医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL
International journal of molecular medicine Pub Date : 2024-11-01 Epub Date: 2024-09-20 DOI:10.3892/ijmm.2024.5426
Yixuan Ma, Yimin Huang, Feng Hu, Kai Shu
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引用次数: 0

摘要

胶质瘤是儿童和成人中最常见的脑部恶性肿瘤。小胶质细胞是中枢神经系统(CNS)中的常住细胞,分布于大脑各处,在中枢神经系统的免疫中发挥着重要作用。小胶质细胞在胶质瘤发展的不同阶段表现出不同的表型和代谢特性,使其成为一个高度动态的细胞群。特别是,胶质瘤相关小胶质细胞/巨噬细胞(GAMs)可改变其代谢特性,并根据其接收到的信号影响恶性肿瘤。近年来,人们越来越认识到巨噬细胞代谢重编程在肿瘤生长中的重要性。然而,据我们所知,目前有关胶质瘤环境下小胶质细胞/巨噬细胞脂质代谢特征的研究数据还很少。因此,本综述旨在全面回顾脂质代谢在肿瘤相关巨噬细胞中的作用。此外,本综述还概述了基于脂质代谢的潜在治疗靶点。本综述旨在为今后研究 GAMs 提供参考资料。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Lipid metabolic rewiring in glioma‑associated microglia/macrophages (Review).

Gliomas are the most prevailing brain malignancy in both children and adults. Microglia, which are resident in the central nervous system (CNS), are distributed throughout the brain and serve an important role in the immunity of the CNS. Microglial cells exhibit varying phenotypic and metabolic properties during different stages of glioma development, making them a highly dynamic cell population. In particular, glioma‑associated microglia/macrophages (GAMs) can alter their metabolic characteristics and influence malignancies in response to the signals they receive. The significance of macrophage metabolic reprogramming in tumor growth is becoming increasingly acknowledged in recent years. However, to the best of our knowledge, there is currently a scarcity of data from investigations into the lipid metabolic profiles of microglia/macrophages in the glioma setting. Therefore, the present review aims to provide a thorough review of the role that lipid metabolism serves in tumor‑associated macrophages. In addition, it outlines potential targets for therapy based on lipid metabolism. The present review aims to serve as a reference source for future investigations into GAMs.

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来源期刊
International journal of molecular medicine
International journal of molecular medicine 医学-医学:研究与实验
CiteScore
12.30
自引率
0.00%
发文量
124
审稿时长
3 months
期刊介绍: The main aim of Spandidos Publications is to facilitate scientific communication in a clear, concise and objective manner, while striving to provide prompt publication of original works of high quality. The journals largely concentrate on molecular and experimental medicine, oncology, clinical and experimental cancer treatment and biomedical research. All journals published by Spandidos Publications Ltd. maintain the highest standards of quality, and the members of their Editorial Boards are world-renowned scientists.
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