重度情感障碍诊断和自杀症状严重程度对抑制控制功能和促炎细胞因子的不同影响:对 800 名青少年和成年人的单点分析。

IF 4.5 2区 医学 Q1 CLINICAL NEUROLOGY
Ya-Mei Bai, Mu-Hong Chen, Ju-Wei Hsu, Hsiang-Hsuan Huang, Jia-Shyun Jeng, Shih-Jen Tsai
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引用次数: 0

摘要

背景:抑制控制功能和促炎细胞因子在重性情感障碍和自杀行为的病理机制中起着一定作用。然而,重性情感障碍和自杀症状严重程度对抑制控制功能和促炎细胞因子的不同影响或交互影响仍不清楚:这项研究包括 287 名双相情感障碍患者、344 名重度抑郁障碍患者和 169 名健康对照者。我们根据蒙哥马利-阿斯伯格抑郁量表(MADRS)第10项(自杀症状)的得分将参与者分为三组:0分、2分或3分以及≥4分。参与者完成了去/不去任务,并测量了C反应蛋白(CRP)和肿瘤坏死因子-α(TNF-α)的水平:结果:无论自杀症状和诊断的严重程度如何,去/不去任务中的错误都与自杀有关(p = .040)。CRP水平的升高与MADRS第10项得分≥4尤其相关(p = 0.001)。TNF-α水平的升高可将双相情感障碍与重度抑郁障碍区分开来(p < .001):我们的研究表明,重度情感障碍诊断和自杀症状严重程度对抑制控制功能、CRP和TNF-α水平有不同的影响。重要的是,抑制控制功能最差、CRP水平最高的个体具有更严重的自杀症状。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Distinct Effects of Major Affective Disorder Diagnoses and Suicidal Symptom Severity on Inhibitory Control Function and Proinflammatory Cytokines: Single-Site Analysis of 800 Adolescents and Adults.

Background: Inhibitory control function and proinflammatory cytokines play a role in the pathomechanisms underlying major affective disorders and suicidal behavior. However, the distinct or interactive effects of major affective disorders and suicidal symptom severity on inhibitory control function and proinflammatory cytokines remain unclear.

Methods: This study included 287 patients with bipolar disorder, 344 with major depressive disorder, and 169 healthy controls. We categorized the participants into 3 groups based on Montgomery-Åsberg Depression Rating Scale (MADRS) item 10 (suicidal symptoms) score: 0, 2 or 3, and ≥4. The participants completed the go/no-go task and the measurements for C-reactive protein (CRP) and tumor necrosis factor-α (TNF-α) levels.

Results: Errors in the go/no-go task were associated with suicidality (P = .040), regardless of the severity of suicidal symptoms and diagnosis. An elevated CRP level was especially associated with a Montgomery-Åsberg Depression Rating Scale item 10 score ≥4 (P = .001). An increased TNF-α level could distinguish bipolar disorder from major depressive disorder (P < .001).

Discussion: Our study indicated the distinct effects of major affective disorder diagnosis and suicide symptom severity on inhibitory control function and CRP and TNF-α levels. Importantly, individuals with the poorest inhibitory control function and highest CRP levels had more severe suicidal symptoms.

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来源期刊
CiteScore
8.40
自引率
2.10%
发文量
230
审稿时长
4-8 weeks
期刊介绍: The central focus of the journal is on research that advances understanding of existing and new neuropsychopharmacological agents including their mode of action and clinical application or provides insights into the biological basis of psychiatric disorders and thereby advances their pharmacological treatment. Such research may derive from the full spectrum of biological and psychological fields of inquiry encompassing classical and novel techniques in neuropsychopharmacology as well as strategies such as neuroimaging, genetics, psychoneuroendocrinology and neuropsychology.
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