宫颈癌方面尚未满足的需求--生物疗法能否填补空白?

IF 3.6 3区 医学 Q2 BIOTECHNOLOGY & APPLIED MICROBIOLOGY
Expert Opinion on Biological Therapy Pub Date : 2024-10-01 Epub Date: 2024-09-25 DOI:10.1080/14712598.2024.2408754
Michelle Greenman, Yifan Emily Chang, Blair McNamara, Levent Mutlu, Alessandro D Santin
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引用次数: 0

摘要

导言:宫颈癌仍是全球最常见的妇科恶性肿瘤之一。由于筛查和治疗不足,发展中国家的发病率过高。即使是接受了充分治疗的患者,如果存在局部晚期或复发疾病,治疗效果也往往不佳。生物制剂疗法的引入提高了患者的总体生存率,但仍有很大的机会来改善目前的治疗标准。生物制剂已在多种肿瘤类型中显示出抗肿瘤活性,目前正被积极用于宫颈癌的治疗:在本文中,我们将讨论宫颈癌生物疗法的历史演变,包括血管生成抑制剂、免疫检查点抑制剂、抗体药物共轭物和疫苗的使用。我们将回顾这些疗法是如何被纳入目前的治疗建议的,并讨论旨在改善临床效果的持续研究。我们还将对治疗中持续存在的差距进行假设:生物疗法对我们目前治疗宫颈癌的方法产生了巨大影响。我们预计将有更多的研究和开发工作投入到对宫颈癌生物制剂的持续研究中,以努力改善这种历来难以治疗的恶性肿瘤。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Unmet needs in cervical cancer - can biological therapies plug the gap?

Introduction: Cervical cancer remains one of the most common gynecologic malignancies worldwide. A disproportionate burden of cases occurs in developing countries due to inadequate screening and treatment. Even among patients adequately treated, in the presence of locally advanced or recurrent disease, outcomes tend to be poor. The introduction of biologic therapy into treatment has increased overall survival; however, a considerable opportunity still exists to improve current standards in treatment. Biologics have shown antitumor activity in multiple tumor types and are actively being pursued for the management of cervical cancer.

Areas covered: In this article, we will discuss the historical evolution of biologic therapy in cervical cancer including use of angiogenesis inhibitors, immune checkpoint inhibitors, antibody-drug conjugates, and vaccines. We will review how these therapies have been integrated into current treatment recommendations and discuss ongoing investigations intended to improve clinical outcomes. We also postulate on persistent gaps in care.

Expert opinion: Biologic therapies have had a tremendous impact on our current approach to managing cervical cancer. We anticipate that significant more research and development will be committed to the continued investigation of biologics in cervical cancer in an effort to improve a historically difficult to treat malignancy.

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来源期刊
Expert Opinion on Biological Therapy
Expert Opinion on Biological Therapy 医学-生物工程与应用微生物
CiteScore
8.60
自引率
0.00%
发文量
96
审稿时长
3-8 weeks
期刊介绍: Expert Opinion on Biological Therapy (1471-2598; 1744-7682) is a MEDLINE-indexed, international journal publishing peer-reviewed research across all aspects of biological therapy. Each article is structured to incorporate the author’s own expert opinion on the impact of the topic on research and clinical practice and the scope for future development. The audience consists of scientists and managers in the healthcare and biopharmaceutical industries and others closely involved in the development and application of biological therapies for the treatment of human disease. The journal welcomes: Reviews covering therapeutic antibodies and vaccines, peptides and proteins, gene therapies and gene transfer technologies, cell-based therapies and regenerative medicine Drug evaluations reviewing the clinical data on a particular biological agent Original research papers reporting the results of clinical investigations on biological agents and biotherapeutic-based studies with a strong link to clinical practice Comprehensive coverage in each review is complemented by the unique Expert Collection format and includes the following sections: Expert Opinion – a personal view of the data presented in the article, a discussion on the developments that are likely to be important in the future, and the avenues of research likely to become exciting as further studies yield more detailed results; Article Highlights – an executive summary of the author’s most critical points.
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