治疗癌症的草药疗法:植物疗法疗效综述》。

IF 5.3 Q1 MEDICINE, RESEARCH & EXPERIMENTAL
Biologics : Targets & Therapy Pub Date : 2024-09-10 eCollection Date: 2024-01-01 DOI:10.2147/BTT.S484068
Andrej Jenča, David K Mills, Hadis Ghasemi, Elham Saberian, Andrej Jenča, Amir Mohammad Karimi Forood, Adriána Petrášová, Janka Jenčová, Zeinab Jabbari Velisdeh, Hadi Zare-Zardini, Meysam Ebrahimifar
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引用次数: 0

摘要

天然产品的化学结构和生物活性多种多样,已被证明是很有前途的抗癌剂。这篇综述探讨了它们在癌症治疗中的核心作用,重点关注其作用机制和治疗效果。药用植物含有生物活性化合物,如黄酮类、生物碱、萜类和多酚,具有多种抗癌特性。这些化合物可诱导细胞凋亡、抑制细胞增殖和细胞周期进展、干扰微管的形成、作用于拓扑异构酶靶点、抑制血管生成、调节关键信号通路、改善肿瘤微环境、逆转耐药性和激活免疫细胞。中草药抗癌药物具有治疗优势,特别是对癌细胞具有选择性毒性,减少了传统化疗的不良副作用。最近的研究和临床试验突出显示了中草药在减轻副作用、提高化疗耐受性以及与常规治疗产生协同效应方面的优势。例如,研究发现草药 SH003 对治疗实体癌安全且具有潜在疗效,而褐藻糖胶具有抗炎特性,对晚期癌症患者有益。目前,有关草药抗癌剂的研究十分广泛。大量研究和临床试验正在调查这些药物对肺癌、前列腺癌、乳腺癌和肝细胞癌等各种癌症的疗效、安全性和作用机制。前景看好的发展包括多药理学方法、联合疗法、免疫调节和改善生活质量。然而,天然产品作为抗癌药物的开发和使用仍面临挑战,例如需要进一步研究其作用机制、可能的药物相互作用和最佳剂量。草药提取物的标准化、生物利用度和给药方式的改进以及监管和接受障碍的克服都是亟待解决的关键问题。尽管如此,天然产品具有良好的抗癌效果和治疗作用,值得进一步研究和开发。多学科合作对于推进草药癌症疗法并将这些药物纳入主流癌症治疗至关重要。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Herbal Therapies for Cancer Treatment: A Review of Phytotherapeutic Efficacy.

Natural products have proven to be promising anti-cancer agents due to their diverse chemical structures and bioactivity. This review examines their central role in cancer treatment, focusing on their mechanisms of action and therapeutic benefits. Medicinal plants contain bioactive compounds, such as flavonoids, alkaloids, terpenoids and polyphenols, which exhibit various anticancer properties. These compounds induce apoptosis, inhibit cell proliferation and cell cycle progression, interfere with microtubule formation, act on topoisomerase targets, inhibit angiogenesis, modulate key signaling pathways, improve the tumor microenvironment, reverse drug resistance and activate immune cells. Herbal anti-cancer drugs offer therapeutic advantages, particularly selective toxicity against cancer cells, reducing the adverse side effects associated with conventional chemotherapy. Recent studies and clinical trials highlight the benefits of herbal medicines in alleviating side effects, improving tolerance to chemotherapy and the occurrence of synergistic effects with conventional treatments. For example, the herbal medicine SH003 was found to be safe and potentially effective in the treatment of solid cancers, while Fucoidan showed anti-inflammatory properties that are beneficial for patients with advanced cancer. The current research landscape on herbal anticancer agents is extensive. Numerous studies and clinical trials are investigating their efficacy, safety and mechanisms of action in various cancers such as lung, prostate, breast and hepatocellular carcinoma. Promising developments include the polypharmacological approach, combination therapies, immunomodulation and the improvement of quality of life. However, there are still challenges in the development and use of natural products as anti-cancer drugs, such as the need for further research into their mechanisms of action, possible drug interactions and optimal dosage. Standardizing herbal extracts, improving bioavailability and delivery, and overcoming regulatory and acceptance hurdles are critical issues that need to be addressed. Nonetheless, the promising anticancer effects and therapeutic benefits of natural products warrant further investigation and development. Multidisciplinary collaboration is essential to advance herbal cancer therapy and integrate these agents into mainstream cancer treatment.

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来源期刊
Biologics : Targets & Therapy
Biologics : Targets & Therapy MEDICINE, RESEARCH & EXPERIMENTAL-
CiteScore
8.30
自引率
0.00%
发文量
22
审稿时长
16 weeks
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