Gui Lian Xiao, Tao Wang, Jiong Kuang, Wen Li Mai, Hua Liu, Shi Ping Ma, Mohammad Hassan Sohouli, Somaye Fatahi, Chengwen Li, Shufang Zou
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The combined results demonstrated that, as compared to the control group, leptin levels in all populations are significantly lower when KD is adhered to (WMD: − 0.14 ng/ml, 95% CI: − 8.66, − 3.61, <i>P</i> < 0.001). On the other hand, no discernible impact of this diet on ghrelin and adiponectin concentrations was noted. The subgroup analysis results demonstrated that the drop in leptin levels was considerably higher in persons with BMI > 30 kg/m<sup>2</sup> and in trials that followed the KD for ≤ 8 weeks than in the other groups.</p><h3>Conclusions</h3><p>Generally speaking, this diet can be utilized as a potentially helpful supplementary therapy to improve this adipokine, given the significance that leptin plays on numerous metabolic illnesses.</p></div>","PeriodicalId":6921,"journal":{"name":"Acta Diabetologica","volume":"61 12","pages":"1495 - 1510"},"PeriodicalIF":3.1000,"publicationDate":"2024-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"The effect of ketogenic diet on adipokines levels: a systematic review and meta-analysis of randomized-controlled trials\",\"authors\":\"Gui Lian Xiao, Tao Wang, Jiong Kuang, Wen Li Mai, Hua Liu, Shi Ping Ma, Mohammad Hassan Sohouli, Somaye Fatahi, Chengwen Li, Shufang Zou\",\"doi\":\"10.1007/s00592-024-02362-6\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Background</h3><p>Considering the impact of adipokines on metabolic syndrome-related disorders and even chronic illnesses, it would appear vital to look for efficient treatments for these variables. 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The effect of ketogenic diet on adipokines levels: a systematic review and meta-analysis of randomized-controlled trials
Background
Considering the impact of adipokines on metabolic syndrome-related disorders and even chronic illnesses, it would appear vital to look for efficient treatments for these variables. The goal of this study was to thoroughly examine how the ketogenic diet (KD) affects adipokines.
Methods
Using standard keywords, the databases Scopus, PubMed/Medline, Web of Science, Cochrane, and Embase were searched to find all controlled trials looking into how KD affected adipokines (leptin, adiponectin, and ghrelin). By using a random-effects model analysis, pooled weighted mean difference and 95% confidence intervals were obtained.
Results
This article featured twenty-two studies. The combined results demonstrated that, as compared to the control group, leptin levels in all populations are significantly lower when KD is adhered to (WMD: − 0.14 ng/ml, 95% CI: − 8.66, − 3.61, P < 0.001). On the other hand, no discernible impact of this diet on ghrelin and adiponectin concentrations was noted. The subgroup analysis results demonstrated that the drop in leptin levels was considerably higher in persons with BMI > 30 kg/m2 and in trials that followed the KD for ≤ 8 weeks than in the other groups.
Conclusions
Generally speaking, this diet can be utilized as a potentially helpful supplementary therapy to improve this adipokine, given the significance that leptin plays on numerous metabolic illnesses.
期刊介绍：
Acta Diabetologica is a journal that publishes reports of experimental and clinical research on diabetes mellitus and related metabolic diseases. Original contributions on biochemical, physiological, pathophysiological and clinical aspects of research on diabetes and metabolic diseases are welcome. Reports are published in the form of original articles, short communications and letters to the editor. Invited reviews and editorials are also published. A Methodology forum, which publishes contributions on methodological aspects of diabetes in vivo and in vitro, is also available. The Editor-in-chief will be pleased to consider articles describing new techniques (e.g., new transplantation methods, metabolic models), of innovative importance in the field of diabetes/metabolism. Finally, workshop reports are also welcome in Acta Diabetologica.
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