先天免疫冠军:巨噬细胞的多种功能

IF 4.5 3区 医学 Q2 IMMUNOLOGY
Francesca Biscu, Anissa Zouzaf, Donatella Cicia, Clare Pridans, Gianluca Matteoli
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引用次数: 0

摘要

巨噬细胞在维持组织稳态、调节炎症和促进再生方面发挥着重要作用。随着全息技术的出现,人们发现了许多组织特异性巨噬细胞亚型,从而提出了 "巨噬细胞生态位 "的概念。这一范式强调了巨噬细胞根据环境线索(如组织特异性信号)调整自身功能的能力。这种适应能力与巨噬细胞的新陈代谢状态密切相关,而新陈代谢状态对巨噬细胞的功能以及在健康和疾病中的作用至关重要。巨噬细胞的新陈代谢是其在促炎和抗炎状态之间切换的核心能力。在这方面,环境因素,包括细胞外基质、细胞相互作用和微生物代谢产物,都会对巨噬细胞的行为产生深远影响。此外,饮食和肠道微生物群对巨噬细胞的功能也有重大影响,营养物质和微生物代谢物会影响巨噬细胞的活性,并导致炎症性肠病等疾病。针对巨噬细胞的特定功能及其代谢过程,正在开发出治疗一系列慢性炎症的新型疗法。对巨噬细胞生物学的探索丰富了我们对免疫调节的认识,有望以创新方法治疗以炎症和免疫功能障碍为特征的疾病,为科学和临床进步提供了一个前沿领域。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Innate immunity champions: The diverse functions of macrophages

Innate immunity champions: The diverse functions of macrophages

Macrophages are instrumental in maintaining tissue homeostasis, modulating inflammation, and driving regeneration. The advent of omics techniques has led to the identification of numerous tissue-specific macrophage subtypes, thereby introducing the concept of the “macrophage niche”. This paradigm underscores the ability of macrophages to adapt their functions based on environmental cues, such as tissue-specific signals. This adaptability is closely linked to their metabolic states, which are crucial for their function and role in health and disease. Macrophage metabolism is central to their ability to switch between proinflammatory and anti-inflammatory states. In this regard, environmental factors, including the extracellular matrix, cellular interactions, and microbial metabolites, profoundly influence macrophage behavior. Moreover, diet and gut microbiota significantly impact macrophage function, with nutrients and microbial metabolites influencing their activity and contributing to conditions like inflammatory bowel disease. Targeting specific macrophage functions and their metabolic processes is leading to the development of novel treatments for a range of chronic inflammatory conditions. The exploration of macrophage biology enriches our understanding of immune regulation and holds the promise of innovative approaches to managing diseases marked by inflammation and immune dysfunction, offering a frontier for scientific and clinical advancement.

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来源期刊
CiteScore
8.30
自引率
3.70%
发文量
224
审稿时长
2 months
期刊介绍: The European Journal of Immunology (EJI) is an official journal of EFIS. Established in 1971, EJI continues to serve the needs of the global immunology community covering basic, translational and clinical research, ranging from adaptive and innate immunity through to vaccines and immunotherapy, cancer, autoimmunity, allergy and more. Mechanistic insights and thought-provoking immunological findings are of interest, as are studies using the latest omics technologies. We offer fast track review for competitive situations, including recently scooped papers, format free submission, transparent and fair peer review and more as detailed in our policies.
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