诊断为 1 型糖尿病时儿童的糖尿病家族史和临床特征--一项基于瑞典人群的研究

IF 14.8 1区医学 Q1 ENDOCRINOLOGY & METABOLISM

Diabetes Care Pub Date : 2024-09-20 DOI:10.2337/dc24-0534

Emma Hedlund, Jasaman Tojjar, Lisa Lilja, Helena Elding Larsson, Gun Forsander, Johnny Ludvigsson, Claude Marcus, Fredrik Norström, Martina Persson, Annelie Carlsson

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引用次数: 0

摘要

目的比较 1 型糖尿病 (T1D) 患儿和非 1 型糖尿病患儿的父母糖尿病患病率，并比较有糖尿病家族史和无糖尿病家族史的儿童确诊 T1D 时的临床特征。研究设计与方法将患有 T1D 的儿童中父母患有糖尿病的情况与普通人群进行比较。使用相对风险 (RR) 和方差分析比较了 3603 名 T1D 儿童的父母和祖父母的临床特征。结果 T1D 患儿的父母患有 2 型糖尿病 (T2D) (RR 1.88; P < 0.001) 的比例高于未患糖尿病的儿童。有 T1D 和 T2D 家族史的儿童更有可能超重或肥胖（P = 0.002）。结论有 T2D 家族史和超重可能会增加患 T1D 的风险。

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Family History of Diabetes and Clinical Characteristics in Children at Diagnosis of Type 1 Diabetes—A Swedish Population-Based Study

OBJECTIVE To compare the prevalence of parental diabetes between children with and without type 1 diabetes (T1D), and to compare clinical characteristics at diagnosis of T1D in children with, versus without, a family history of diabetes. RESEARCH DESIGN AND METHODS Parental diabetes among children with T1D was compared with a general population cohort. Clinical characteristics were compared by family history of diabetes in parents and grandparents of 3,603 children with T1D using relative risk (RR) and ANOVA. RESULTS Children with T1D more often had parents with type 2 diabetes (T2D) (RR 1.88; P < 0.001) than did children without diabetes. Children with T1D and a family history of T2D were more likely to be overweight or obese (P = 0.002). CONCLUSIONS A family history of T2D and being overweight may contribute to increased risk of T1D.

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来源期刊

Diabetes Care 医学-内分泌学与代谢

CiteScore

27.80

自引率

4.90%

发文量

449

审稿时长

1 months

期刊介绍： The journal's overarching mission can be captured by the simple word "Care," reflecting its commitment to enhancing patient well-being. Diabetes Care aims to support better patient care by addressing the comprehensive needs of healthcare professionals dedicated to managing diabetes. Diabetes Care serves as a valuable resource for healthcare practitioners, aiming to advance knowledge, foster research, and improve diabetes management. The journal publishes original research across various categories, including Clinical Care, Education, Nutrition, Psychosocial Research, Epidemiology, Health Services Research, Emerging Treatments and Technologies, Pathophysiology, Complications, and Cardiovascular and Metabolic Risk. Additionally, Diabetes Care features ADA statements, consensus reports, review articles, letters to the editor, and health/medical news, appealing to a diverse audience of physicians, researchers, psychologists, educators, and other healthcare professionals.