Meta-analysis of 65 Adamantinoma case reports: Unveiling symptomatology, demographics, and treatment outcomes in contrast to prior understandings

Adamantinomas are rare, malignant bone tumors predominantly affecting the tibia. This study compares demographics, clinical presentations, radiographic findings, metastasis rates, and treatment outcomes of adamantinoma cases from a contemporary review of 65 cases with a historical review by Keeney et al. (1989). Our data reveals a significant increase in the average age at diagnosis, from 25.9 years in the prior study to 38.1 years in the new study, with notable increases for both males and females. The metastasis rate in our study was 45.3 %, significantly higher than the 23.5 % reported previously with a wider range of possible sites. Treatment options have changed with significant improvement in survivability and remission with allograft and endoprosthesis techniques compared to older techniques of amputation and resection. This study highlights the evolving understanding of adamantinoma, emphasizing the changes in presentation and the effectiveness of advanced surgical treatments.